University Of Rochester

This study tests whether adding a preventive procedure called pulmonary vein isolation (PVI) to the standard ablation for typical atrial flutter can reduce the risk of heart-related hospital visits, stroke, or death. The trial enrolls adults aged 55 and older with an enlarged lef…

This study tests whether a higher dose of caffeine citrate can improve breathing and reduce complications in extremely premature infants (born before 28 weeks). Forty babies will be randomly assigned to receive either a high or standard dose of caffeine, starting at one week old.…

This study tests a program where children with asthma take their daily medicine at school, supervised by staff. The goal is to see if this helps more children take their medicine correctly and reduces asthma attacks. The trial will include 300 children in Rochester, New York, and…

This study tests a combination of three drugs (cladribine, low dose cytarabine, and venetoclax) in 24 adults with acute myeloid leukemia (AML) that has relapsed or not responded to prior treatment, especially after a venetoclax-based regimen. The goal is to see if this combinatio…

This study tests whether adding a light-activated blue dye treatment to standard abscess drainage can clear infection faster. About 120 adults with deep abscesses will get either standard drainage alone or drainage plus the dye treatment. The main goal is to see if the dye treatm…

This study tests whether giving children a single inhaler for both daily control and quick symptom relief at school can reduce asthma attacks and emergency visits. About 330 children aged 6–12 with moderate-to-severe asthma will take part across Rochester City schools. School nur…

This study compares an oral iron supplement (sucrosomial iron) to the usual intravenous (IV) iron given to anemic patients before heart surgery. About 75 adults with mild anemia scheduled for heart procedures will be randomly assigned to one of the two treatments. The goal is to …

This phase 2 study tests whether adding methylene blue photodynamic therapy (MB-PDT) to standard drainage helps breast abscesses heal faster. Fifty adults with breast abscesses will either receive standard drainage alone or drainage plus MB-PDT. The main goal is to see how quickl…

This study tests whether text messages and easy referrals can help more smokers get screened for lung cancer. About 1,036 emergency department patients who smoke or recently quit will be randomly assigned to receive a simple referral, a facilitated referral, or text message remin…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This observational study will follow 50 people receiving chemotherapy that often causes nausea and vomiting. Researchers want to see if those who use medical cannabis on their own have less nausea, better appetite, and fewer other side effects compared to those who don't use it. …

This study tests whether a 16-week home exercise program can improve daily function in 30 adults with pulmonary hypertension linked to interstitial lung disease. Participants will receive daily texts or emails with aerobic and strength exercises. Researchers will measure changes …

This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several …

This study tests whether adding diphenhydramine (an antihistamine) to standard sedation medicine reduces pain during first-trimester abortion. About 98 adults will receive either diphenhydramine or a placebo alongside usual care. The goal is to see if this simple addition improve…

This study looks at whether a 6-week home program combining exercise and a limited eating window is practical and helpful for breast cancer survivors who are on hormone therapy and feel fatigued. Twenty participants will follow a plan to increase their steps, do resistance band e…

This study tests whether a whole food, plant-based diet combined with behavioral education can improve quality of life and diet adherence in 60 women with metastatic breast or endometrial cancer. Participants are randomly assigned to either the plant-based diet with support or a …

This study tests a coaching program called Social Engage Coaching (S-ENG) for adults aged 60 and older who feel lonely. The program includes 10 one-on-one sessions to help participants build social connections and find activities that matter to them. Researchers will measure chan…

This early-stage trial tests amlodipine, a calcium channel blocker used for high blood pressure, in 20 adults with myotonic dystrophy type 1. The goal is to see if the drug is safe and can improve muscle strength, reduce stiffness, and help with daily function. All participants w…

This study will test a treatment called rTMS, which uses magnetic pulses to stimulate parts of the brain, in 20 women with fibromyalgia. The goal is to see if stimulating the motor cortex changes brain activity and reduces pain. Researchers will use MRI scans to compare effects o…

This study will observe how the Impella 5.5 heart pump changes the way the heart squeezes and works in adults with end-stage heart failure. Researchers will use ultrasound (echocardiography) to measure heart function before, right after, and 7-14 days after the pump is placed. Th…

This study will observe how healthy lungs work by using two non-invasive tests: a special MRI that shows lung ventilation and a breathing test that measures airway resistance. Twenty healthy adults will participate to help researchers understand the relationship between these mea…

This study is testing a new tool to help older adults (65+) with metastatic breast cancer and their care partners make treatment decisions together. Researchers want to see if the tool is acceptable, appropriate, and practical for use. The study involves 150 participants and focu…