Can we predict who benefits from a heart device? new study aims to find out

NCT ID NCT06977217

Ongoing Knowledge-focused Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will follow 270 patients for 12 months to see if certain tests before implantation can predict who will improve. The goal is to develop a scoring system to help doctors choose the right patients for this therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cardiac resynchronization therapy with a defibrillator (CRT-D)
What this could lead to: If successful, this could help doctors identify which heart failure patients without a specific ECG pattern will benefit most from CRT-D, improving outcomes and avoiding unnecessary procedures.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new therapy. The findings may not apply to all patients, and the predictive score needs further validation before clinical use.

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Conditions

The condition(s) this trial relates to.

cardiomyopathy heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC RESYNCHRONIZATION THERAPY CARDIOMYOPATHIES HEART FAILURE NON-LEFT BUNDLE BRANCH BLOCK

Contacts and locations

Locations

University of Rochester Medical Center

Rochester, New York, 14642, United States

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