CARDIOMYOPATHIES

This study is testing whether a specific type of heart pacing, called high-intensity His bundle pacing, can improve heart function in patients with heart failure who have a 'narrow QRS' on their ECG. Researchers will implant a special pacemaker/defibrillator in about 34 participa…

This study tests whether adding a heart rhythm procedure during heart pump (LVAD) surgery reduces dangerous irregular heartbeats afterward. It involves 100 patients with advanced heart failure and a history of serious rhythm problems. Half will receive the extra rhythm surgery du…

This study is testing whether a focused radiation treatment can better control dangerous rapid heart rhythms compared to the standard catheter procedure. Researchers will enroll 60 patients with advanced heart disease who experience these life-threatening rhythms. They'll compare…

This early-stage study is testing the safety of a new gene therapy for the serious heart muscle damage that occurs in people with Friedreich's ataxia. The therapy, called AAVrh.10hFXN, is given through an IV and aims to deliver a working copy of the frataxin gene directly to the …

This study aims to test the safety and effectiveness of a heart-lung support machine called the Cardiohelp System in children with life-threatening heart failure. It will also compare two different blood thinners used with the device. The goal is to gather enough evidence for the…

This study is testing whether new artificial intelligence software can read heart rhythm tracings as accurately as a cardiologist. The software analyzes electrocardiogram (ECG) data from over 5,000 high-risk heart patients to detect dangerous patterns and predict serious events. …

This study is testing if a simple wristband can estimate how well the heart pumps blood, which is usually measured with an ultrasound machine. Researchers will enroll 500 adults who are already scheduled for a standard heart ultrasound. They will wear the wristband during their s…

This study is testing whether a new drug called acoramidis can prevent or delay heart and nerve damage in people who carry a gene for a serious disease but don't yet have symptoms. About 582 adults aged 18-75 with the genetic risk will receive either the drug or a placebo to see …

This study creates an online registry to follow 10,000 adults with cardiomyopathy or myocarditis over time. Participants share health information and provide saliva samples for genetic testing. Researchers aim to better understand these heart conditions by tracking outcomes like …

This study aims to learn why some people with weakened hearts are at higher risk of sudden cardiac death. Researchers will follow 1,500 patients who already have an implanted defibrillator, collecting health data over many years. The goal is to find better markers—like blood test…

This study aims to understand if people with epilepsy who are at high risk of sudden death might have an underlying genetic heart condition. Researchers are recruiting 600 adults with epilepsy or their family members to provide DNA samples for genetic testing. The goal is to iden…

This study aims to learn more about how a specific inherited heart condition (PKP2-ACM) progresses over time in people receiving standard care. Researchers will observe 36 patients who have this genetic variant and an implanted heart device, collecting data on their heart health,…

This study aims to better understand various heart diseases by analyzing small tissue samples taken during routine heart biopsies. Researchers will examine these samples to identify patterns and markers associated with different heart conditions. The goal is to improve future dia…