CARDIOMYOPATHIES

This study tests whether a non-invasive radiation treatment (SBRT) can reduce dangerous heart rhythms as effectively as the standard catheter ablation procedure in 60 people with advanced heart disease. Participants will be randomly assigned to receive either radiation or cathete…

This study tests a new gene therapy for heart disease caused by Friedreich's ataxia, a rare genetic disorder. The treatment uses a harmless virus to deliver a working copy of the frataxin gene. Researchers will check safety and early signs of benefit in 25 people aged 12 to 50.

This study tests the Cardiohelp device, a heart-lung machine, in 50 children with severe heart failure to see if it is safe and works well for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. Th…

This study tests whether destroying abnormal heart tissue (ablation) during LVAD surgery can reduce dangerous heart rhythms after the operation. About 100 adults with advanced heart failure who are getting an LVAD will be enrolled. The goal is to see if this extra procedure lower…

This study tests a special pacing method called high-intensity his bundle pacing in 34 people with heart failure and a narrow QRS pattern on their ECG. Standard pacing doesn't help this group, but this new approach may improve heart function and quality of life. Participants will…

This study tests an experimental drug called acoramidis in 587 adults who carry a gene mutation for transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a protein in the blood to prevent it from forming harmful plaques in the heart and nerves. If …

This study follows people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life over time to better understand how the disease naturally progresses. No new treatments are given; participants c…

This study is an online registry that follows 10,000 adults with cardiomyopathy or myocarditis over time. Researchers will track serious heart events like heart failure, dangerous heart rhythms, and death. No treatments or tests are given—it simply collects information to better …

This study aims to find genetic heart problems that might explain why some people with epilepsy die suddenly. Researchers will test 600 adults aged 18-50 with epilepsy, seizures, or related events, plus their blood relatives. They use advanced gene sequencing to look for known he…

This study follows 1,500 people with heart failure who already have an implantable defibrillator (ICD). The goal is to learn which patients are at highest risk of sudden cardiac death by looking at heart structure, electrical signals, genetics, and blood markers. This information…

This study is testing a cloud-based artificial intelligence program called Willem that reads electrocardiograms (ECGs) to detect heart rhythm problems and other abnormal patterns. Researchers will compare the AI's performance to that of board-certified cardiologists using data fr…

This study is testing whether a special wristwatch that shines light through the skin (called PPG) can estimate how well the heart pumps blood and detect heart valve or muscle diseases. About 500 adults getting a heart ultrasound will wear the watch to see if its signals match st…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns for different heart conditions, like cardiomyopathy and heart transplant recovery. The goal is to improve how doctors diagn…