CARDIOMYOPATHIES

This study tests the Cardiohelp device, a heart-lung machine, in 50 children with severe heart failure to see if it is safe and works well for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. Th…

This study tests if a non-invasive radiation treatment (SBRT) can reduce dangerous heart rhythms better than the standard catheter ablation procedure in 60 people with advanced heart disease. Participants will be randomly assigned to receive either radiation or catheter ablation.…

This study tests whether destroying abnormal heart tissue (ablation) during LVAD surgery can reduce dangerous heart rhythms after the operation. About 100 adults with advanced heart failure who are getting an LVAD will be enrolled. The goal is to see if this extra procedure lower…

This study tests a special pacing method called high-intensity his bundle pacing in 34 people with heart failure and a narrow QRS pattern on their ECG. Standard pacing doesn't help this group, but this new approach may improve heart function and quality of life. Participants will…

This is an early-stage study testing the safety of a new gene therapy for the heart damage caused by Friedreich's ataxia. The therapy uses a modified virus to deliver a healthy gene directly to the heart. Researchers will enroll 25 participants to find a safe dose and look for ea…

This study tests an experimental drug called acoramidis in 587 adults who carry a gene mutation for transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a protein in the blood to prevent it from forming harmful plaques in the heart and nerves. If …

This study follows 36 people with a rare genetic heart condition called PKP2-ACM to track how the disease progresses over time. Participants receive standard care while researchers monitor heart rhythms, biomarkers, and quality of life. The goal is to better understand the condit…

This study follows 1,500 people with heart failure who already have an implantable defibrillator (ICD). The goal is to learn which patients are at highest risk of sudden cardiac death by looking at heart structure, electrical signals, genetics, and blood markers. This information…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns for different heart conditions, like cardiomyopathy and heart transplant recovery. The goal is to improve how doctors diagn…

This study is testing a new artificial intelligence (AI) program called Willem that reads electrocardiograms (ECGs) — the test that records your heart's electrical activity. Researchers want to see if the AI can spot dangerous heart rhythms as well as a human heart specialist. Ov…

This study creates an online registry for 10,000 adults with cardiomyopathy or myocarditis, plus those with a family history. Researchers will track heart-related deaths, arrhythmias, and major heart failure events over time. No treatments are given—it's purely observational to b…

This study is testing whether a special watch that shines light on the skin (called PPG) can predict how well the heart pumps blood and detect heart valve or muscle diseases. About 500 adults getting a heart ultrasound will wear the watch to collect data. Researchers will use art…

This study is looking for genetic heart problems in people with epilepsy that might raise their risk of sudden unexpected death. Researchers will test DNA from 600 adults and their relatives to find known heart-related gene changes. The goal is to better understand why some epile…