Liver clues: a new way to stage heart amyloidosis?

NCT ID NCT07766135

First seen Aug 14, 2026 ยท Last updated Aug 14, 2026

Summary

This study looks at whether liver function and blood clotting tests can help doctors better understand and monitor cardiac transthyretin amyloidosis (ATTR-CA), a condition where abnormal protein builds up in the heart. Researchers will compare these tests in people with ATTR-CA against those with another type of heart muscle disease. They will also check if these markers change after 6 and 12 months of treatment with tafamidis, a medication used for this condition. The goal is to find new tools for staging the disease and tracking its progression.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Observational study with no intervention; evaluates tafamidis effects on liver and coagulation markers.
What this could lead to
If successful, this could lead to new markers for staging and tracking cardiac amyloidosis, improving patient monitoring and care.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may not change clinical practice without further validation.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AOU Policlinico G. Martino, UOC Cardiologia con UTIC

    RECRUITING

    Messina, Sicily, 98124, Italy

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