Can a daily pill keep a rare heart disease in check for the long haul?

NCT ID NCT07116473

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests the long-term safety and tolerability of acoramidis, an oral medication that stabilizes the transthyretin protein, in people newly diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition that can lead to heart failure. Participants who completed an earlier study of acoramidis may join this extension, where they will continue taking the drug twice daily. Researchers will monitor for side effects and changes in health measures over time to see if the drug remains safe for extended use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
acoramidis (AG10), an oral drug that stabilizes the transthyretin protein to prevent amyloid buildup
What this could lead to
If successful, this could confirm acoramidis as a safe long-term treatment option for people with transthyretin amyloid cardiomyopathy, potentially slowing disease progression.
What could go wrong
This is an extension study focused on safety, not new efficacy data. Long-term use may still reveal side effects, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

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