A hidden warning in your wrist? surgery may reveal heart risk
NCT ID NCT05793320
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This study tests whether tissue taken during routine carpal tunnel release surgery can help diagnose amyloidosis, a condition where abnormal proteins build up in organs. People with bilateral carpal tunnel syndrome and certain risk factors—like age, heart issues, or family history—will have a biopsy during surgery. If the biopsy is positive, they'll be referred to a cardiologist for further heart evaluation. The goal is to see if carpal tunnel syndrome can serve as an early warning sign for amyloidosis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Carpal tunnel release surgery with tissue biopsy
- What this could lead to
- If it works, this could lead to earlier detection of amyloidosis, allowing timely heart care and better outcomes.
- What could go wrong
- The study is exploratory and may not prove that biopsy findings reliably predict heart amyloidosis. Risks include surgical complications and false positives.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Henry Ford Main Campus
Detroit, Michigan, 48202, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Hidden amyloid in heart valves: a new clue in aortic stenosis?
- New nerve patch could ease pain after biopsy
- Heart rhythm risks in ATTR amyloidosis patients on tafamidis under scrutiny