Henry Ford Health System

This study tests whether eating 50 grams of peanuts daily for 12 weeks can improve liver markers and gut health in adults with metabolic fatty liver disease (MASLD). 125 participants will be randomly assigned to either eat peanuts or stick to their regular diet. Researchers will …

This study combines two treatments—laser heat to destroy tumors near the spinal cord and precise radiation—to better control spine tumors that have spread from other cancers. About 60 adults with solid tumors will receive both therapies. The goal is to improve tumor control, redu…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This study tests whether using portable air cleaners at home after a heart failure hospital stay can improve heart health. About 400 adults will receive either a real air cleaner or a fake one. Researchers will measure changes in a heart stress marker and track hospital readmissi…

This study tests whether the drug budesonide can prevent fevers caused by engraftment syndrome after a stem cell transplant. About 110 adults with blood cancers will receive budesonide starting 5 days after transplant, and researchers will compare their fever rates to those who d…

This study compares two types of radiation therapy for people with liver cancer (hepatocellular carcinoma). One method delivers radiation directly to the tumor through a small tube in an artery, while the other uses a precise external beam. The goal is to see which approach bette…

This study compares standard rotator cuff surgery to surgery plus a bioinductive patch that aims to help the tendon heal better. About 78 adults with full-thickness tears will be randomly assigned to one of the two groups. The main goal is to see if the patch leads to fewer tendo…

This early-phase study tests whether adding a drug made from urine (uhCG/EGF) to standard therapy can safely prevent graft-versus-host disease (GVHD) in stem cell transplant patients with partially matched donors. About 18 adults with blood cancers who lack a fully matched donor …

This phase 2 trial tests whether low-dose azacitidine can help maintain donor cell levels (chimerism) in patients with MDS, AML, or related blood cancers after an allogeneic stem cell transplant. About 43 adults whose donor cell levels are dropping will receive azacitidine for at…

This study tests a stem cell transplant using a half-matched (haploidentical) donor for people with blood cancers who don't have a fully matched donor. The approach uses chemotherapy and radiation before transplant, plus drugs like cyclophosphamide and bortezomib after to prevent…

This early-stage study tests whether combining two drugs (sacituzumab govitecan and capecitabine) is safe for people with advanced gastrointestinal cancers that have stopped responding to standard treatments. About 20 adults with stomach, colorectal, or pancreatic cancer will tak…

This early-phase trial tests a new approach for people with recurrent high-grade astrocytomas, a type of aggressive brain cancer. During surgery to remove the tumor, doctors inject a modified virus directly into the brain cavity, followed by targeted radiation. The main goal is t…

This study tests whether a program using community health workers and medication can lower blood pressure and prevent heart failure in 364 adults from Detroit and Cleveland. Participants with high blood pressure or risk factors will receive personalized support and medication. Th…

This study tests whether a medication called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during surgery. About 10 adults with known or suspected tumors will take 5-ALA before their procedure. The goal is to see if this technique…

This study tests whether a mindfulness-based sleep program for pregnant women with insomnia can prevent depression during and after pregnancy. Researchers will enroll 500 women and compare the program to standard care. The goal is to improve sleep and reduce the risk of perinatal…

This trial tests whether ketorolac, a non-opioid anti-inflammatory drug, can control pain after hip arthroscopy as well as or better than standard opioid medications. About 100 adults with femoroacetabular impingement undergoing hip arthroscopy will be randomly assigned to receiv…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study looks at how well corticosteroid injections relieve carpal tunnel syndrome symptoms in people whose nerve tests (EMG) are normal or only mildly abnormal. Researchers will review past data from 300 patients who received the injection and filled out a questionnaire about…

This study tests a mobile app called SHIFT that uses data from an Apple Watch to give personalized light exposure advice, helping night shift workers sleep better. Researchers will enroll 300 night shift workers who have poor sleep. The goal is to see if the app improves sleep, h…

This study tests a cooling device placed inside the mouth during radiation therapy for larynx cancer. The goal is to see if cooling can protect taste buds from radiation damage and prevent loss of taste. About 15 adults with advanced larynx cancer will try the device and report t…

This study compares two types of prostate cancer surgery: radical prostatectomy, which removes the entire prostate and surrounding tissue, and precision prostatectomy, which removes most of the prostate but spares nerves and structures important for urinary control and sexual fun…

This small phase 2 trial is testing whether tranexamic acid, a drug used to reduce bleeding, can lighten dark patches on the skin caused by lichen planus pigmentosus and erythema dyschromicum perstans. Five adults will take the drug twice daily for six months. Researchers will me…

This study looks at whether combining jail release records with electronic health records can help connect people to suicide prevention services after they leave jail. Researchers will track suicide attempts and deaths among 5,250 adults released from jail in Michigan and Minneso…

This study is testing whether two blood markers, CXCL9 and EASIX, can predict severe acute graft-versus-host disease (GVHD) after a stem cell transplant. Researchers will take blood samples from 100 adult patients 28 days after transplant to see if these markers can spot early si…

This study aims to improve how sleep is measured for nightshift workers, whose inverted schedules make standard sleep trackers inaccurate. Researchers will use an Apple Watch along with machine learning to better detect daytime sleep. About 100 nightshift workers will participate…

This study aims to find the best time to measure cervical length during a standard pregnancy ultrasound (anatomy scan) to improve accuracy. Researchers will compare measurements taken at the start versus the end of the scan in 550 pregnant individuals. They will also test if a sp…

This study looks at how antibiotics given during a stem cell transplant change the bacteria in your gut. Researchers will track these changes in 255 adults getting a transplant for blood cancers or bone marrow failure. The goal is to understand the link between antibiotics and gu…

This study aims to see if giving patients with alcohol-related liver disease customized alcohol treatment choices increases their participation in therapy or support groups. Researchers will enroll 268 adults from University of Michigan clinics and hospitals. The main goal is to …

This pilot study aims to see if a brief educational session can increase the number of Black men with aggressive prostate cancer who complete genetic testing. Researchers will enroll 50 men who identify as Black or multiracial and have high-risk prostate cancer. Participants will…

This study is collecting temperature data from 30 adults undergoing HIPEC surgery, a procedure where heated chemotherapy is delivered directly into the abdomen. Researchers will use this data to build a computer model that can predict how body temperature changes during the opera…

This study looks at whether a person's tendency to have trouble sleeping when stressed (called sleep reactivity) is a main cause of Shift Work Disorder. Researchers will reduce the mismatch between workers' body clocks and their nightshift schedule, then see if those with high sl…