Henry Ford Health System

This study compares two types of radiation therapy for people with liver cancer (hepatocellular carcinoma). One method delivers tiny radioactive beads directly to the tumor, while the other uses focused external beams. The goal is to see which approach better controls the cancer …

This early-phase study tests a combination of two drugs, sacituzumab govitecan and capecitabine, in people with advanced gastrointestinal cancers (such as stomach, colon, or pancreatic cancer) that have stopped responding to standard treatments. The main goal is to find a safe an…

This early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…

This study tests whether a low dose of the drug azacitidine can help maintain or increase the level of donor cells in patients with certain blood cancers (MDS, AML, CMML, MPN) after a stem cell transplant. The goal is to reduce the chance of the cancer coming back. About 43 adult…

This early-phase study tests whether adding two natural proteins (uhCG/EGF) to standard post-transplant chemotherapy can safely prevent graft-versus-host disease (GVHD) in patients receiving stem cells from partially matched donors. About 18 adults with blood cancers who lack a f…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain blood vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and impro…

This study is for people with blood cancers who need a stem cell transplant but don't have a perfectly matched donor. It uses stem cells from a half-matched family donor along with special drugs to help the body accept the new cells and prevent complications. The main goal is to …

This study compares standard rotator cuff repair surgery to surgery with an added bioinductive implant. The implant is designed to help the tendon heal more completely. About 78 adults with full-thickness tears will be randomly assigned to one of the two groups. The main goal is …

This study is testing whether a drug called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during a procedure. About 10 adults with known or suspected tumors will take 5-ALA before surgery, and doctors will use a special light to s…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to coach people on managing blood pressure and other risk factors. About 364 adults with high blood pressure or early signs of heart failure will receive support to …

This study tests a mindfulness-based sleep program for pregnant women with insomnia to see if it can prevent depression during and after pregnancy. 500 participants will be assigned to either the sleep program or standard care. The goal is to improve sleep and reduce the risk of …

This study looks at how long symptom relief lasts after a corticosteroid injection for carpal tunnel syndrome in people whose nerve tests (EMG) are normal or only mildly abnormal. Researchers will review medical records from 300 adults to see how well the injection works. The goa…

This study tests a smartphone app called SHIFT that gives personalized lighting and sleep tips to night shift workers. Researchers want to see if using the app helps people sleep longer, feel better, and be more productive at work. 300 night shift workers who currently sleep less…

This study looks at ways to help people complete an online program for insomnia called digital cognitive behavioral therapy (dCBT-I). Researchers will track 600 adults with insomnia to see what factors—like sleep environment or daily habits—affect whether people finish the progra…

This study compares two types of prostate cancer surgery: the standard radical prostatectomy and a newer precision prostatectomy that aims to spare nerves and tissues. The goal is to see if the precision approach helps men recover sexual and urinary function better while still co…

This study tests a special cooling mouthpiece used during radiation therapy for larynx cancer. The goal is to see if cooling the mouth can prevent or reduce taste loss, a common side effect of radiation. About 15 adults with advanced larynx cancer will try the device and report c…

This early study tests whether tranexamic acid, a drug used for heavy bleeding, can reduce dark patches in two rare skin conditions: lichen planus pigmentosus and ashy dermatosis. Researchers will enroll 5 adults and measure pigment changes with special devices. The goal is to se…

This study compares a nonopioid pain control regimen to standard opioid painkillers in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid approach can manage pain just as well while avoiding opioid side effects. Participants are randomly assigned…

This pilot study looks at whether a simple educational session can increase the number of Black men with high-risk prostate cancer who complete genetic testing. Researchers will enroll 50 men who identify as Black or multiracial, provide a brief teaching session on genetic testin…

This study looks at whether giving people with alcohol-related liver disease personalized options for alcohol treatment helps them actually start and stay in treatment. Researchers will also correct common misunderstandings about treatment. About 268 adults from University of Mic…

This study looks at when during a pregnancy ultrasound it is best to measure the cervix (the lower part of the womb) to better predict preterm birth. About 550 pregnant women will be randomly assigned to have the measurement at the start or end of their routine anatomy scan. The …

This study is creating a computer model to better predict body temperature changes during a special type of heated chemotherapy surgery called HIPEC. Researchers will collect temperature data from 30 adults undergoing HIPEC for abdominal cancer. The goal is to improve temperature…

This study aims to improve how sleep is measured for nightshift workers, whose inverted schedules make standard sleep trackers inaccurate. Researchers will use data from Apple Watches and other sensors, combined with machine learning, to better detect daytime sleep. About 100 nig…

This study is looking at how antibiotics given during a stem cell transplant affect the bacteria in your gut. Researchers will track changes in the microbiome over time in 255 adults aged 18-80 who are getting a stem cell transplant for blood cancer or bone marrow failure. The go…

This study looks at whether being sensitive to stress-related sleep problems (called sleep reactivity) is a key cause of Shift Work Disorder. Researchers will reduce the mismatch between workers' body clocks and their night shift schedule, then see if those with high sleep reacti…

This study looks at whether two blood markers, CXCL9 and EASIX, can predict severe acute graft-versus-host disease (GVHD) before symptoms appear. Researchers will measure these markers in 100 adults receiving a stem cell transplant for blood cancer. The goal is to improve early d…

This study looks at whether combining jail release records with electronic health records can help connect people to suicide prevention services. Over 5,000 adults released from jail who have recently visited a doctor or mental health provider will be included. Researchers will t…