Can pressurized oxygen boost cord blood transplants?

NCT ID NCT03739502

Ongoing Disease control Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests whether giving patients hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) after an umbilical cord blood stem cell transplant helps the donated stem cells grow faster. The trial enrolls people with blood cancers like leukemia or lymphoma who lack a matched donor. The goal is to see if this approach shortens the time to immune recovery and reduces complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen therapy
What this could lead to: If it works, this could speed up recovery of the immune system after cord blood transplants, reducing infection risk and hospital stays.
What could go wrong: This is a small, early-phase study, so results may not be conclusive. Hyperbaric oxygen can cause ear or sinus discomfort and, rarely, lung issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute lymphoblastic leukemia acute myeloid leukemia acute undifferentiated leukemia classic Hodgkin lymphoma Hodgkins lymphoma myelodysplastic syndrome Myelodysplastic Syndromes myeloproliferative neoplasm non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALL AML HODGKIN DISEASE MYELODYSPLASTIC SYNDROME NHL

Contacts and locations

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Locations

University of Rochester

Rochester, New York, 14642, United States

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