ALL

This early-phase trial is testing whether adding the targeted drug ruxolitinib to standard chemotherapy is safe for adolescents and young adults (ages 12-39) with a specific, high-risk form of acute lymphoblastic leukemia called Ph-like ALL. The study aims to find the best dose a…

This study tests a treatment called CD19 CAR-T cell therapy in 50 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The therapy uses a patient's own immune cells, modified to find and attack leukemia cells. The main goal is to see if the treatme…

This study tests a new automated method to select specific stem cells (CD34+) for patients with blood cancers who need a stem cell boost or second transplant. The goal is to lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the pa…

This study tests a drug called inotuzumab ozogamicin in people with acute lymphoblastic leukemia (ALL) who still have tiny amounts of cancer cells (called minimal residual disease, or MRD) after a stem cell transplant. The goal is to see if the drug can clear these remaining cell…

This study tests whether a cord blood transplant can help children and young adults (up to age 21) with life-threatening blood cancers or non-cancerous blood disorders who do not have a matched family donor. The main goal is to see how many patients are alive without treatment-re…

This study follows about 1,000 people who previously received an experimental T-cell therapy (TSC-100 or TSC-101) for blood cancers like leukemia. Researchers will track participants for up to 15 years to see if any long-term side effects occur and how well they survive. The goal…

This study creates a registry of Amish and Mennonite people who are interested in joining future medical research. Researchers will use the registry to find volunteers whose family health history matches new studies. The goal is to learn more about health conditions that affect t…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…