Heart rhythm rematch: does extra scarring boost ablation success?

NCT ID NCT06988202

ENROLLING_BY_INVITATION Disease control Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares two ways to repeat a heart ablation for people with persistent atrial fibrillation (AF) whose first ablation didn't work. The standard repeat method isolates the pulmonary veins; the experimental method also treats the left atrial posterior wall. Researchers will track how symptoms change over time in 630 participants to see which approach leads to better heart rhythm control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: catheter ablation procedure (pulmonary vein isolation with or without left atrial posterior wall isolation)
What this could lead to: If adding left atrial posterior wall isolation works better, it could offer a more effective repeat treatment for people with persistent atrial fibrillation, reducing symptoms and the need for further procedures.
What could go wrong: This is a mid-stage comparative study, not a final proof of cure. The added step may not improve outcomes and could carry extra risks like damage to nearby structures. Results may not apply to all AF patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ATRIAL FIBRILLATION (AF) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF)

Contacts and locations

Locations

University of Rochester Clinical Cardiovascular Research Center

Rochester, New York, 14642, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.