Heart rhythm rematch: does extra scarring boost ablation success?
NCT ID NCT06988202
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares two ways to repeat a heart ablation for people with persistent atrial fibrillation (AF) whose first ablation didn't work. The standard repeat method isolates the pulmonary veins; the experimental method also treats the left atrial posterior wall. Researchers will track how symptoms change over time in 630 participants to see which approach leads to better heart rhythm control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
catheter ablation procedure (pulmonary vein isolation with or without left atrial posterior wall isolation)
What this could lead to
If adding left atrial posterior wall isolation works better, it could offer a more effective repeat treatment for people with persistent atrial fibrillation, reducing symptoms and the need for further procedures.
What could go wrong
This is a mid-stage comparative study, not a final proof of cure. The added step may not improve outcomes and could carry extra risks like damage to nearby structures. Results may not apply to all AF patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Rochester Clinical Cardiovascular Research Center
Rochester, New York, 14642, United States