Can a sleep pill stop Post-Surgery delirium?

NCT ID NCT07217912

Recruiting now Prevention Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery in adults aged 60 and older. Participants take the drug or a placebo for three nights after surgery and are monitored for delirium and sleep quality. The goal is to gather data for a larger trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: daridorexant
What this could lead to: If it works, this could point toward a way to prevent delirium after heart surgery, reducing confusion and improving recovery for older patients.
What could go wrong: This is a small, early-phase pilot study with only 80 participants, so results may not be conclusive. The drug may not reduce delirium or could cause side effects like daytime drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction delirium Emergence Delirium Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE COGNITIVE DECLINE POSTOPERATIVE DELIRIUM

Contacts and locations

Locations

University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States

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