POSTOPERATIVE DELIRIUM

This study tests whether carefully managing body temperature during major cancer surgery can lower the risk of postoperative delirium (sudden confusion) and improve long-term survival in patients aged 65 and older. About 4,000 participants will be randomly assigned to either rout…

This study tests whether doing simple, home-based brain exercises for a few weeks before heart surgery can help prevent postoperative delirium (sudden confusion) and long-term memory problems. Researchers will enroll 100 adults scheduled for elective heart surgery. Half will do t…

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery in adults aged 60 and older. Participants take the drug or a placebo for three nights after surgery and are monitored for delirium and sleep quality. The goal is…

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in older adults (65+) after hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surge…

This study tests whether relaxing before heart surgery using virtual reality nature scenes or special sound patterns (binaural beats) can reduce stress and prevent problems like confusion or memory loss after the operation. About 125 adults having planned heart surgery will be ra…

This study looks at whether keeping a patient's blood pressure within their personal safe range during heart surgery can reduce brain problems like confusion, stroke, or memory issues. Researchers will monitor 500 patients having heart surgery and track their blood pressure and b…

This study is observing 150 older adults (65+) who are having major orthopedic surgery, like hip or knee replacement. Researchers want to see if feeling distressed before surgery is linked to problems after surgery, such as confusion (delirium), pain, and longer hospital stays. T…

This study compares two common anesthesia methods—intravenous drugs and inhaled gases—to see how they affect thinking skills after sleeve gastrectomy (weight-loss surgery). Researchers will measure how quickly patients wake up and follow commands, and test their memory and attent…

This huge study of 100,000 adults compares two common anesthetics—propofol and sevoflurane—to see which one lowers the risk of postoperative delirium (sudden confusion after surgery). Researchers will track patients for 5 days after elective surgery. The goal is to provide clear …

This study looks at whether the Naples Prognostic Score, a combination of blood markers, can predict postoperative delirium in elderly patients having hip fracture surgery. Researchers will enroll 168 people aged 60 and older and check for delirium daily using a standard assessme…

This study tracks 270 older adults (65+) having non-cardiac surgery to see how often they develop postoperative delirium—sudden confusion after an operation. Researchers will look at risk factors like age, frailty, and health conditions, and follow patients to see how delirium af…

This study is looking at whether simple blood tests can help predict which children might become confused or agitated after waking up from anesthesia for circumcision. Researchers will check inflammation levels in the blood before surgery and watch for signs of delirium in the re…

This study follows 1,500 adults having planned heart surgery to learn why some become confused or delirious afterward. Researchers will look at factors before surgery that raise the risk, and track patients over time to see how delirium affects their recovery and long-term health…

This observational study is testing whether non-invasive monitors that track brain electrical activity and oxygen levels can help determine the best blood pressure to maintain during major non-cardiac surgery in people over 60. The goal is to see if these monitors can reliably gu…

This study looks at whether certain proteins in the blood can predict postoperative delirium (sudden confusion after surgery) in elderly patients with diabetes. Researchers will measure levels of TGF-β, ADNP, MAP6, and PGC-1α in 180 participants before surgery and track who devel…