Massive study aims to end debate: which anesthetic causes less Post-Surgery confusion?

NCT ID NCT07612579

Recruiting now Knowledge-focused Sponsor: Charite University, Berlin, Germany Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This huge study of 100,000 adults compares two common anesthetics—propofol and sevoflurane—to see which one lowers the risk of postoperative delirium (sudden confusion after surgery). Researchers will track patients for 5 days after elective surgery. The goal is to provide clear evidence for future anesthesia guidelines and potentially reduce delirium cases in aging populations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propofol and sevoflurane (anesthetic drugs)
What this could lead to: If it works, this could show which anesthetic technique reduces delirium risk after surgery, leading to updated hospital guidelines and fewer cases of confusion in older patients.
What could go wrong: This is an observational study, not a controlled trial, so results may show correlation, not causation. Delirium has many causes, so even a large study may not give a clear answer.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE DELIRIUM

Contacts and locations

Locations

Department of Anesthesiology and Intensive Care Medicine (CBF), Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 12203, Germany
Department of Anesthesiology and Intensive Care Medicine Berlin
RECRUITING

Berlin, 13353, Germany

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