Charite University, Berlin, Germany

This study tests whether adding the drug bortezomib to standard chemotherapy helps children and teens with high-risk relapsed acute lymphoblastic leukemia (ALL) achieve remission and live longer. About 250 participants under 18 will be randomly assigned to receive either standard…

This study looks at whether a blood-filtering treatment called immunoadsorption (IA) can improve symptoms in people with ME/CFS (chronic fatigue syndrome) or post-COVID ME/CFS who have certain autoantibodies. Researchers will track 50 patients over time to see if removing these a…

This study tests whether a gentle nerve stimulation technique (tVNS) can make mindfulness training more effective at preventing relapse in people recovering from alcohol dependence. 140 detoxified patients will practice mindfulness with or without the stimulation. Researchers wil…

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check their quality. The goal is to safely use livers that were previously considered unsuitable, helping 186 people on the transplant waiting list …

This study is testing a new type of heart valve made from a patient's own tissue to treat a leaky pulmonary valve. Seven adults will receive the valve to see if it is safe and works well in the short term. The valve is designed to grow with the patient, potentially reducing the n…

This study tests a 12-week digital exercise program for people who had ACL knee surgery. The program uses sensors to help correct how the knee moves during walking, with the goal of reducing joint inflammation and preventing osteoarthritis. Researchers will enroll 60 adults aged …

This study tests whether a dermatologist's physical exam or a patient questionnaire is better at finding psoriatic arthritis (PsA) in people with psoriasis. About 500 adults with psoriasis will be screened both ways, then checked by a rheumatologist for a final diagnosis. The goa…

This study tests whether people who have had a heart attack and have a weak heart can safely avoid getting a defibrillator implant if they take the latest heart medications. About 3,600 participants will be randomly assigned to receive either a defibrillator plus drugs or drugs a…

This study tests a hospital care program to prevent delirium (sudden confusion) in older patients after surgery. About 18,100 people aged 70 and older will take part. The program uses proven steps and electronic records to catch and treat early signs of confusion.

This study tests whether giving oxytocin (a natural hormone) as a nasal spray before group mindfulness therapy can reduce negative symptoms like lack of motivation and social withdrawal in people with schizophrenia. About 120 adults will receive either a low or high dose of oxyto…

This study aims to reduce suffering for adults in the intensive care unit (ICU) by providing palliative care consultations. Researchers will track how long patients stay in the ICU and whether these consultations help them leave sooner. The study involves 2,040 participants acros…

This study is testing whether a yoga-based group program can help people with schizophrenia spectrum disorders feel better and manage their symptoms. Researchers are comparing yoga to simple strength and flexibility exercises and to standard care alone. The goal is to see if the …

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The goal is to see if the app is …

This study tests if acupuncture, with or without mild electrical stimulation, can help women with multiple sclerosis who have bladder control issues. 150 women aged 18-60 will be randomly assigned to one of three groups. The goal is to see which method better reduces symptoms lik…

This study is testing a self-guided internet program called Velibra for people with anxiety disorders who are on a waitlist for treatment. The program uses cognitive behavioral therapy techniques to help reduce symptoms. About 30 adults with panic disorder, social anxiety, or gen…

This study looks at why people who have been in the intensive care unit (ICU) do not attend their scheduled follow-up appointments. Researchers will review medical records of 2,500 patients to find patterns and reasons for missed visits. The goal is to improve attendance and make…

This study looks at electronic health records from up to 1 million patients who had anesthesia or intensive care at a large hospital since 2016. Researchers will use data science to find patterns in routine information that are linked to better or worse patient outcomes. The goal…

This study follows up with 434 older adults from an earlier study (BioCog) to see how their thinking and memory have changed over 7 to 10 years. Participants take simple cognitive tests on a web app from home. The goal is to understand long-term cognitive changes, not to treat or…

This study tracks brain activity in 25 people with dystonia who are getting deep brain stimulation (DBS). Researchers want to find brain signals that show how well the treatment is working, so therapy can be adjusted faster and more precisely. Participants will use a special pace…

This study looks at whether changes in how hospitals prepare children for heart surgery or catheterization can lower their stress and anxiety. Researchers will measure anxiety levels in 100 children before their procedure and compare them to a previous group. The goal is to find …

This study tests whether adding realistic smells to virtual reality scenes can help people with alcohol dependence manage their cravings. Researchers will have 20 participants experience VR environments with alcohol-related scents and measure how well they tolerate it and whether…

This study looks back at medical records of 200 people with severe lung failure (ARDS) to see how their immune system affects the chance of getting extra infections like herpes or cytomegalovirus. Researchers will measure immune cells and virus levels in blood and lung fluid. No …

This study looks at why people with multiple sclerosis (MS) feel so tired. Researchers will use a gentle, non-invasive brain stimulation technique called tDCS to see if it can change brain activity and reduce fatigue. 84 adults with relapsing-remitting MS will take part, and the …

This study looks at whether intensive care units that follow certain quality care steps have better patient results and lower costs. Researchers will review data from about 26,000 adults who stayed in the ICU for more than 24 hours. The goal is to find which quality measures matt…

This study looks at how pregnant and non-pregnant patients recover after being in the intensive care unit (ICU) for COVID-19 and lung failure. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after the ICU stay. The goal is to better un…

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed right heart valve. Researchers will check participants' health through blood tests, heart ultrasounds, and medical records for two months after the procedure. The goal is to learn which…

This study looks at how well CFTR modulator drugs work in people with cystic fibrosis. Researchers will measure CFTR function using sweat chloride tests and other methods in 500 participants. The goal is to better understand the drugs' effects in real-world use.

This study watches 2,500 adults with chronic diseases who receive a mix of traditional, complementary, and integrative medicine (TCIM) during hospital stays in Germany. Therapies include heat treatment, exercise, mind-body medicine, herbs, nutrition, and fasting. The goal is to s…

This study looks at whether increasing dopamine can help with motivation and movement problems in people with major depression who have signs of inflammation. Researchers will give a dopamine-boosting drug or a placebo to 165 participants (depressed patients and healthy volunteer…

This study looks at whether taking estradiol (a form of estrogen) can help reduce the number of intrusive, unwanted memories after a traumatic event. Healthy female volunteers will watch a stressful film and then take either estradiol or a placebo. Researchers will track how many…

This study tests a personalized breathing maneuver in children on ventilators—either after heart surgery or with severe lung failure. The goal is to see if adjusting the breathing machine settings can improve heart and lung function, reduce time on the ventilator, and lower the n…

This study interviews 60 prostate cancer patients and their relatives to learn about their needs during and after radiation therapy. Researchers also want to know if patients are interested in prehabilitation programs to prepare for treatment. The goal is to improve support and c…

This study is for adults aged 45 and older with various cancers who are about to start radiotherapy. Researchers want to see how much protein patients eat before, during, and after treatment, and whether that affects muscle mass and quality of life. The goal is to understand the …

This study looks at whether a 4-week time-restricted eating (TRE) plan can improve how well older adults respond to flu and COVID-19 vaccines. Researchers will measure changes in immune cell activity and body composition in 24 healthy volunteers aged 60-85. The goal is to underst…

This study aims to find out how often people experience memory and thinking problems after surgery. Researchers will look at data from 5000 patients who had surgery lasting at least an hour. The goal is to better understand these issues, not to test a new treatment.

This study looks at using a computer program (machine learning) to help doctors diagnose sepsis and septic shock more quickly. Researchers will analyze data from 10,000 ICU patients to see if the algorithm can spot warning signs earlier than current methods. The goal is to speed …

This study tests whether a special lighting program can help restore natural day-night rhythms in intensive care patients who are confused (delirious). Researchers will measure melatonin and other body clock markers in 40 adults, comparing the new light approach to standard hospi…