New breathing technique could help critically ill kids on ventilators
NCT ID NCT07193719
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a personalized lung volume optimization maneuver can improve heart and lung function in children on ventilators. It includes two groups: children recovering from heart surgery and those with severe respiratory failure. Researchers will adjust ventilator pressure to find the best lung volume for each child and measure effects on blood flow, oxygen levels, and breathing mechanics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lung volume optimization maneuver (PEEP titration)
- What this could lead to
- If successful, this could establish a standard method to improve breathing and heart function in critically ill children on ventilators, potentially reducing time on life support.
- What could go wrong
- This is an early-phase study with only 80 participants, so results may not apply broadly. The maneuver involves adjusting ventilator pressure, which could temporarily affect heart function or lung stability.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
German Heart Center of the Charité
RECRUITINGBerlin, 13353, Germany
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