CONGENITAL HEART DISEASE

This is an early-stage safety study testing whether heart cells grown in a lab from a patient's own skin are safe to give to adults with severe congenital heart disease and heart failure. The study will enroll 50 participants who are not eligible for or are waiting too long for a…

This study is looking at whether a special type of pacemaker can safely and effectively treat dangerously fast heart rhythms in people born with heart defects. Researchers will review the medical records of up to 300 adults and children who already have these pacemakers implanted…

This study is testing if a common heart drug called propranolol can safely and effectively treat a serious complication called chylothorax in children recovering from heart surgery. Chylothorax is a buildup of fluid in the chest that can delay recovery. Researchers will give 50 c…

This study is testing whether a medication called sacubitril-valsartan, often used for heart failure, can improve the heart's structure and function in adults who were born with heart defects. Researchers will compare the drug to a placebo in 45 participants, measuring changes in…

This study is testing a specific breathing technique, called a lung volume optimization maneuver, for children in two critical situations. For kids recovering from heart surgery, it aims to see if the technique improves heart function and lung mechanics, potentially shortening th…

This study is testing a Parent Navigator Program to see if it helps Latino parents of babies with congenital heart disease get connected to important developmental follow-up services. Researchers will compare families who receive weekly support calls from a 'navigator' to familie…

This study is testing a digital app called 'EmpowerMyCH' designed to help adults with congenital heart disease better manage their health. The app includes features like a digital medical record, health information, and community support. Researchers want to see if using the app …

This study is testing a home exercise program that uses a special video game-linked exercise bike to help young people with congenital heart disease get fitter. Researchers want to see if this fun, supervised 8-week program improves exercise ability, physical activity levels, and…

This study is testing a small, tube-like device called a stent to keep a specific blood vessel open in babies with severe congenital heart disease. The goal is to safely maintain blood flow until the baby is big enough for more complete heart surgery. Researchers will enroll abou…

This study aims to test the safety and effectiveness of a heart-lung support machine called the Cardiohelp System in children with life-threatening heart failure. It will also compare two different blood thinners used with the device. The goal is to gather enough evidence for the…

This study is testing a new 3D ultrasound imaging technique to better measure heart size and function in children and young adults born with only one working heart pumping chamber. Researchers will compare this new method against the current gold standard, cardiac MRI, to see if …

This study is testing a new, non-invasive imaging vest that creates a 3D map of the heart's electrical activity. It aims to see if this scan can accurately locate the source of irregular heartbeats in adults born with heart defects. The goal is to help doctors better plan treatme…

This study is testing whether using a 3D printed model of a child's heart helps surgeons plan the placement of a life-support device called a VAD. It will compare surgery outcomes for children whose surgeons used a 3D model for planning versus those who used standard 2D scans. Th…

This study is testing whether a 12-week, home-based high-intensity interval training program can improve exercise capacity in teens and adults (ages 12-45) born with specific heart defects that required surgery to create a connection between the heart's right ventricle and lung a…

This study aims to understand how living with a congenital heart condition affects mental health. Researchers will survey and interview 1,000 adults with congenital heart disease to identify which medical and life experiences increase the risk of developing PTSD. The goal is to l…

This study aims to understand why adults who had surgery for congenital heart disease as children still develop problems like shortness of breath and irregular heartbeats later in life. Researchers will observe 300 participants with various repaired heart conditions to measure ch…

This study aims to understand why newborns with severe congenital heart disease are at high risk for dangerous blood clots after surgery. Researchers will collect blood samples from 10 newborns to analyze tiny molecules that may control clotting. The goal is to uncover the biolog…

This study is creating a database of medical journeys from people with congenital heart defects. It aims to gather information from 500 participants to help design future research studies that better address patient needs. Unlike traditional registries, participants actively cont…

This study aims to understand why some patients develop abnormal blood clots during and after heart surgery. Researchers will examine immune cells and inflammatory signals in 100 patients of all ages undergoing complex cardiac procedures. The goal is to identify potential causes …

This study aims to understand hidden heart rhythm problems in fetuses that may lead to stillbirth. Researchers will use a safe, non-invasive magnetic heart monitor on 200 pregnant people with high-risk conditions like prior stillbirth or major fetal heart defects. The goal is to …

This international registry aims to gather real-world information on how a class of drugs called SGLT2 inhibitors is being used in adults born with heart defects. It will track 400 patients who are already prescribed this medication to see how they tolerate it and if it helps imp…

This study aims to gather information on how a common heart condition in premature babies, called a patent ductus arteriosus (PDA), might affect oxygen levels in their kidneys. Researchers will observe 45 very premature infants, using special sensors and heart ultrasounds to meas…

This study aims to understand why and how serious liver scarring develops in adults who had a Fontan procedure for congenital heart disease. Researchers will observe 100 participants over time, collecting blood, stool, and liver tissue samples to identify new markers of disease s…

This study aims to find out which of two common medical tools is better for safely placing a breathing tube through the nose of babies under 1 year old who have heart defects and need surgery. It will compare a standard direct-view tool against a newer video-guided tool. The main…

This study is testing if a smart wristband can help monitor the heart health of pregnant women who were born with a heart condition. The goal is to see if the device can spot early warning signs of heart problems while women are at home. Researchers will enroll 50 participants to…

This study aims to collect heart function data from healthy adults to serve as a comparison group for research on congenital heart disease. Researchers need 50 healthy participants who can undergo MRI scans and heart pressure measurements. The data will help doctors better unders…

This study aims to create a better tool to predict the future heart health of babies diagnosed before birth with a rare heart defect called pulmonary atresia. Researchers will observe 150 pregnancies to see which ultrasound measurements best forecast whether a baby will need majo…

This study aims to understand if a mother's stress, anxiety, or depression during pregnancy affects how her child's brain develops during the first year of life. It will follow about 87 families in France where the baby was diagnosed before birth with a serious heart defect requi…

This study aims to learn if heart tests done during exercise reveal more problems than tests done at rest in people with congenital heart disease. Researchers will enroll 200 adults who are already scheduled for a standard heart catheterization procedure. The goal is to gather in…

This study aims to understand if pulse oximeters, the clip-on devices that measure blood oxygen, are equally accurate for children with different levels of skin pigmentation. It will observe 92 pediatric patients with congenital heart disease who are already scheduled for heart s…