CONGENITAL HEART DISEASE

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This trial tests whether a personalized physical activity plan can help children aged 5–18 with congenital heart disease increase their exercise capacity and daily activity levels. The plan is designed with input from parents, teachers, and a pediatric cardiologist to address saf…

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study looked at whether giving thiamine (vitamin B1) for 28 days after a heart defect repair procedure helps children's hearts recover. The trial included 86 children aged 6 months to 18 years with certain heart defects. Researchers measured heart structure and function usin…

This study tested a new contrast agent called NH002 in 36 adults with heart disease. The agent is used during heart ultrasound to make the heart's chambers and borders clearer. The main goal was to check safety by monitoring vital signs, heart activity, and allergic reactions aft…

This study tested whether using virtual reality glasses during physical therapy can reduce pain, improve blood oxygen levels, and help children walk farther after open heart surgery. Forty children aged 6 to 12 took part. One group used VR glasses during their cardiac rehab exerc…

This study tested if online speech therapy could help babies with congenital heart disease who are fed only through a tube. Twenty babies aged 0 to 12 months received 10 days of online therapy from a speech therapist. The goal was to see if they could drink more milk by mouth and…

This study tested a special nerve block (serratus anterior plane block) to see if it could reduce pain and the need for strong painkillers like fentanyl in children after heart surgery. 48 children having heart surgery through a chest incision took part. The goal was to find a sa…

This study tested if combining cartoon-watching with nurse interaction could ease pain in children after heart surgery. 70 kids aged 3-7 took part; half got standard pain care, and the other half also watched cartoons with a nurse. The goal was to see if this fun, non-drug approa…

This study tested a program called PRISM to help adults with congenital heart disease build resilience and manage stress. 78 adults with moderate or complex heart conditions took part. Researchers checked if the program was feasible and if it improved resilience scores compared t…

This study tested whether online group exercise training could help children aged 6-18 with pacemakers become more active and improve their strength and quality of life. 36 children were split into two groups: one did online exercise sessions three times a week for eight weeks, w…

This study tests whether special low-energy MRI settings can make it safe to use guidewires during heart catheterization. Guidewires help position catheters but can heat up in standard MRI. Researchers will enroll 22 adults who need a right heart catheterization to see if this ap…

This study looked at 40 children with congenital heart disease who had heart surgery. During surgery, doctors used a special filtering technique called SBUF-SMUF to remove inflammatory substances from the blood. The goal was to see how this affected inflammation and recovery. The…

This study looked for genetic causes of congenital heart disease (heart problems present at birth) in families from Uganda and Nigeria. Over 1,200 people took part, including affected children and their parents. Researchers used advanced DNA testing to find gene changes linked to…

This study looked at new ways to test blood clotting in 200 children with congenital heart disease undergoing surgery. The goal was to see if newer technologies like TEG, ROTEM, and T2MR could help doctors manage bleeding more precisely and reduce the need for blood transfusions.…

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to better understand …

This study looked at how well a procedure called catheter ablation works for treating fast heart rhythms in people with congenital heart disease. Researchers treated 40 patients and followed them for one year to see if the abnormal heart rhythm came back. The goal was to understa…

This study measured levels of an inflammatory protein called HMGB1 in 74 children with congenital heart disease and pulmonary hypertension. Researchers compared these levels to those in children with heart disease alone and healthy controls. The goal was to see if inflammation pl…

This study tested whether a small, band-aid-like heart monitor (Zio patch) can be worn by children for up to 14 days. It involved 36 kids aged 1 to 17 years. The goal was to see if the patch sticks well and gives clear heart signals. The study did not test any treatment, only the…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study looked at whether giving extra oxygen to pregnant mothers carrying babies with congenital heart disease (CHD) could increase oxygen levels in the fetal brain. Researchers used ultrasound and MRI to measure changes in 53 fetuses with different types of CHD. The goal was…

This study looked at how different levels of ventilator pressure (PEEP) affect the heart's ability to pump blood in children under 5 with congenital heart disease who are on breathing machines. Researchers measured changes in cardiac output and right heart function in 58 children…

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This study tested two ways to help 16-17 year olds with congenital heart disease learn to manage their health as they move from pediatric to adult care. One group used a smartphone app for 18 months; the other had a single teaching session with a nurse. Researchers measured chang…

This study tested a new, portable ultrasound device that can take a picture of the heart in less than one minute. It was used on 22 infants under 1 year old with congenital heart disease. The goal was to see if the new device's images were as good as the standard ultrasound image…

This study surveyed 106 pediatric cardiologists to understand what they know, think, and do about cardiac rehabilitation for children with congenital heart disease. The goal was to find out why this helpful therapy is underused. Researchers used a questionnaire based on the World…

This study looked at 38 infants under 1 year old with congenital heart disease who needed heart surgery. The goal was to understand why some babies get brain injuries during surgery and to gather data for developing better monitoring tools. Researchers used MRI scans and blood sa…

This study tested a noninvasive monitor that uses light to measure oxygen levels in the liver of children with heart conditions. Researchers wanted to see if this method could replace the usual needle-based blood draw. The study included 100 children undergoing heart catheterizat…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at 60 children having heart surgery with a bypass machine. It compared two types of filters—hemofilters and hemodialyzers—to see which one better removes inflammatory substances called cytokines. The goal was to find out if the cheaper hemodialyzer could be a sa…