Inflammation clues found in kids with rare lung condition
NCT ID NCT03581695
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study measured levels of an inflammatory protein called HMGB1 in 74 children with congenital heart disease and pulmonary hypertension. Researchers compared these levels to those in children with heart disease alone and healthy controls. The goal was to see if inflammation plays a role in this serious lung condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this research could help identify new targets for treating pulmonary hypertension in children with heart disease.
- What could go wrong
- This is an observational study, not a treatment trial. It only measures biomarkers, so it cannot directly improve patient outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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