CONGENITAL HEART DISEASE

This study tests whether adding nitric oxide to the heart-lung machine during surgery can reduce brain and kidney damage in infants with congenital heart disease. Researchers will measure specific proteins in the blood before and after surgery and monitor for confusion and kidney…

This study tests a special heart valve for children aged 1.5 to 16 years with congenital heart disease who need a new pulmonary valve. The valve can be expanded after surgery as the child grows, potentially reducing the need for repeat operations. Researchers will check safety an…

This study looks at how well the Medtronic Harmony Transcatheter Pulmonary Valve (TPV) works when used by doctors in real-world settings. It involves 150 people with certain heart defects who need a new pulmonary valve. The main goal is to see if the valve works properly and does…

This study tests a new device (Alterra Prestent with SAPIEN 3 valve) to fix leaky pulmonary heart valves in people born with heart defects. About 86 participants with moderate or severe leakage will get the device through a tube in a vein, avoiding open-heart surgery. The goal is…

This study tests a new valve (Harmony TPV) that can be placed inside the heart using a thin tube through a blood vessel, avoiding open-heart surgery. It is for people with congenital heart disease who have a leaky valve in the right side of the heart. The study checks if the valv…

This study is testing a new driving system for the Berlin Heart EXCOR, a heart pump used in children with severe heart failure who are waiting for a heart transplant. The goal is to see if the new system works safely and effectively. About 40 children will take part, and the stud…

This study looks at children with congenital heart disease who take the blood thinner rivaroxaban after a Fontan procedure. The goal is to see how often serious or minor bleeding happens in real-world use. Researchers will collect data from medical records of 61 children for up t…

This study planned to check if blood tests taken during and after pregnancy in women with adult congenital heart disease could help predict future heart problems like arrhythmias or heart failure. It also wanted to see if changes in these blood markers over time gave better warni…

This study tests whether special low-energy MRI settings can make it safe to use standard guidewires during heart catheterization. Guidewires help position catheters but can heat up in an MRI machine. Researchers will enroll 22 adults who need a right heart catheterization to see…

This study looks at 224 adults who had surgery as children for a heart defect called tetralogy of Fallot. Researchers want to see if scarring in the heart muscle, measured by MRI and blood tests, is linked to future heart problems like arrhythmias or heart failure. The goal is to…

This study looks at whether proteins in the blood can help predict which children with congenital heart disease will have serious complications after heart surgery. Researchers will measure thousands of proteins from small blood samples and combine them with patient data to build…

This study looks at whether a web-based decision aid helps parents of unborn or newborn babies with life-threatening congenital heart disease make informed medical choices. About 135 parents will be randomly assigned to use the decision aid alone or with an extra values-clarifica…