No-Scalpel heart valve offers new hope for patients with rare heart defects

NCT ID NCT02979587

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 25 times

Summary

This study is testing a new device called the Harmony TPV, a replacement heart valve that can be placed using a thin tube through a blood vessel, avoiding open-heart surgery. It is for people with certain heart defects who have a leaky valve. The goal is to see if the valve works well and is safe over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Mayo Clinic

    Rochester, Minnesota, 55902, United States

  • National Cerebral and Cardiovascular Center

    Suita, Osaka, 565-8565, Japan

  • Nationwide Children's Hospital

    Columbus, Ohio, 43215, United States

  • Primary Children's Hospital

    Salt Lake City, Utah, 84113, United States

  • Ronald Regan UCLA Medical Center

    Los Angeles, California, 90095, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Stanford University Medical Center

    Palo Alto, California, 94304, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

  • The Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • The Hospital for Sick Children (SickKids)

    Toronto, Ontario, M5G 1X8, Canada

  • Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • Yale University

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.