Growing heart valve could spare kids repeat surgeries
NCT ID NCT05006404
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a special heart valve for children aged 1.5 to 16 years with congenital heart disease who need a pulmonary valve replacement. The valve can be expanded after implant to match the child's growth, potentially avoiding multiple surgeries. Researchers will check safety and how well the valve works over 10 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Autus Size-Adjustable Valve (a heart valve device that can be expanded to fit a growing child)
What this could lead to
If successful, this valve could reduce the number of repeat surgeries children need as they grow, offering a more adaptable solution for heart valve replacement.
What could go wrong
This is an early-stage study with only 51 participants, so results may not apply to all children. Risks include device-related complications like blood clots or valve failure.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ann and Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Columbia University Irving Medical Center/New York Presbyterian Morgan Stanley Children's Hospital
New York, New York, 10032, United States
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Duke University
Durham, North Carolina, 27703, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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University of Michigan - Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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University of Utah - Intermountain Primary Children's Hospital
Salt Lake City, Utah, 84113, United States