Could a pacemaker boost exercise capacity in adults with a rare heart condition?

NCT ID NCT05524324

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). Participants already have a CRT device implanted and will be randomly assigned to have it active or inactive for three months, then switch. The study measures exercise capacity, oxygen use, and heart function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cardiac resynchronization therapy (biventricular pacing device)
What this could lead to: If it works, this could show that CRT improves daily function and heart efficiency in adults with this specific heart condition.
What could go wrong: This is a small crossover trial with 26 participants, so results may not apply broadly. The device may not improve symptoms for everyone, and there are standard risks of pacing therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CONGENITAL HEART DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

congenital heart disease congenitally corrected transposition of the great arteries heart failure transposition of the great arteries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEART DISEASE CONGENITALLY CORRECTED TRANSPOSITION OF THE GREAT ARTERIES HEART FAILURE CONGENITAL SYSTEMIC RIGHT VENTRICLE TRANSPOSITION OF GREAT VESSELS

Contacts and locations

Locations

AP-HP, Pitié-Salpétrière

Paris, France
Ap-Hp Hegp

Paris, 75015, France
CHU de Caen

Caen, France
CHU de Lille

Lille, France
CHU de Montpellier

Montpellier, France
CHU de Nantes

Nantes, France
CHU de Rouen

Rouen, France
CHU de Toulouse

Toulouse, France
CHU de Tours

Tours, France
Clinique Pasteur

Toulouse, France
Hôpital La Timone

Marseille, France
Hôpital Louis Pradel

Lyon, France
Hôpital Marie-Lannelongue

Le Plessis-Robinson, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.