Heart drug hope: diabetes meds may help adults born with heart defects

NCT ID NCT06932081

Recruiting now Knowledge-focused Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This international registry is tracking 400 adults with congenital heart disease who are taking SGLT2 inhibitors, a type of diabetes medication that also benefits the heart. Researchers want to see how these drugs are being prescribed, how well they are tolerated, and whether they improve heart failure outcomes. The study is purely observational, meaning it collects real-world data without assigning treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SGLT2 inhibitors (a class of diabetes drugs that help the heart and kidneys)
What this could lead to: If successful, this registry could show that SGLT2 inhibitors are safe and helpful for adults with congenital heart disease, potentially leading to better heart failure management.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by other factors, and the study is relatively small (400 participants).

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Conditions

The condition(s) this trial relates to.

congenital heart disease congenitally corrected transposition of the great arteries heart failure tetralogy of fallot transposition of the great arteries univentricular heart

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT CONGENITAL HEART DISEASE CONGENITAL HEART DISEASE CONGENITALLY CORRECTED TRANSPOSITION OF THE GREAT ARTERIES FONTAN SINGLE-VENTRICLE SYSTEMIC RIGHT VENTRICLE TETRALOGY OF FALLOT (TOF) TRANSPOSITION OF THE GREAT ARTERIES

Contacts and locations

Locations

Amsterdam University Medical Center
RECRUITING

Amsterdam, Netherlands
Barts Heart Centre
RECRUITING

London, United Kingdom
Golden Jubilee University National Hospital
RECRUITING

Glasgow, United Kingdom
Heart Center Duisburg (Evangelical Hospital Niederrhein)
RECRUITING

Duisburg, Germany
Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
Leiden University Medical Center (LUMC)
RECRUITING

Leiden, South Holland, 2333ZA, Netherlands
Mount Sinai Fuster Heart Hospital
RECRUITING

New York, New York, 10029, United States
University Hospital of Wales
RECRUITING

Cardiff, United Kingdom
University Medical Center Utrecht
RECRUITING

Utrecht, Netherlands
Zan Mitrev Clinic
RECRUITING

Skopje, North Macedonia

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