Leiden University Medical Center

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This study tests whether repeated injections of a steroid around a nerve in the back of the head can prevent cluster headache attacks in people with chronic cluster headache. Fifty adults with at least four attacks per week will receive either the steroid or a placebo injection e…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This study is testing a device called Laser Speckle Contrast Imaging (LSCI) that uses a laser to measure blood flow in the leg. The goal is to see if it can help doctors monitor blood flow before, during, and after surgery to restore circulation. The study will enroll 30 people s…

This study is testing whether a simple finger-prick blood sample (dried blood spot) can accurately measure levels of certain cancer drugs in the body. Researchers will compare results from the finger-prick method with standard blood draws in 360 adults taking oral or infused canc…

This study looks at two types of nerve surgery to treat stubborn pain after amputation (phantom limb pain and stump pain). About 98 adults who have had pain for at least 6 months and haven't had prior pain surgery will be followed for 2 years. The goal is to see if either surgery…

This study tests a surgical technique called targeted muscle reinnervation (TMR) to prevent phantom limb pain and stump pain after a leg amputation. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to receive either TMR or standard ne…

This study tests whether 16 weeks of aerobic exercise or cognitive behavioral therapy can reduce severe fatigue in people with myasthenia gravis, a muscle weakness condition. Sixty adults with stable MG will be randomly assigned to exercise, therapy, or usual care. The goal is to…

This international registry is tracking 400 adults with congenital heart disease who are taking SGLT2 inhibitors, a type of diabetes medication that also benefits the heart. Researchers want to see how these drugs are being prescribed, how well they are tolerated, and whether the…

This study is looking at immune markers in the blood of 300 women with ovarian cancer to see if they can predict how the disease will progress. It is an observational study, meaning no treatment is given. The goal is to better understand the role of the immune system in ovarian c…

This study tests a new online tool that gives patients taking five or more medications personalized information about drug interactions and genetic risks. 120 adults from four European countries will use the tool for 12 weeks and answer questionnaires about their understanding an…

This study watches 60 ICU patients on breathing machines to see if a new device (SERA) can measure breathing effort and oxygen use. The goal is to find better ways to predict who can safely breathe without the machine. Participants are already getting a standard breathing test, a…

This study tests a smart technology box for people who have been in the ICU. The goal is to see if it's possible for 50 patients to use the box at home for 12 months to monitor their health and catch problems early. The box is not a treatment, but a way to gather information to i…

This observational study will follow 1900 people with moderate mixed aortic valve disease (a combination of aortic stenosis and regurgitation) to see how symptoms and heart function relate to survival and the need for valve replacement. Researchers hope to identify which patients…

This study will collect data from 1,500 people with liver tumors who are getting a procedure called thermal ablation, which uses heat to destroy tumors. Researchers will use artificial intelligence to analyze the data and find better ways to select patients, plan treatments, and …

This observational study aims to understand why older adults lose certain immune cells (T cells) from their nasal passages, which may make them more prone to respiratory infections. Researchers will compare young adults (18-30), healthy older adults (65+), and frail older adults …

This study will use smartphone recordings of speech, eye movements, and arm fatigue to measure key symptoms of myasthenia gravis, a condition that causes muscle weakness. Researchers will compare 225 participants (both with and without MG) to see if machine learning can accuratel…