Leiden University Medical Center

This study is testing a new web-based tool designed to help patients who take five or more medications. The tool provides personalized information about potential drug interactions and genetic factors that affect medication safety. Researchers want to see if using this tool for 1…

This study is testing whether repeated steroid injections around a nerve at the back of the head can help prevent the severe, recurring pain attacks of chronic cluster headache. Researchers are comparing the injections to a placebo in 50 patients to see if they provide longer-las…

This large national study is testing if customizing blood thinner treatment after hip or knee replacement surgery is safer and more effective than the current standard approach. Researchers will assign over 10,000 patients to receive shorter, longer, or standard treatment based o…

This study is testing a new weekly birth control pill that contains no hormones. Researchers want to see if taking one pill per week is safe, prevents pregnancy effectively, and causes fewer side effects than current daily hormonal options. About 1,200 women will use the pill for…

This study tests whether a specific nerve surgery technique performed during leg amputation can prevent the severe chronic pain that often follows. Researchers are comparing the standard method of cutting nerves to a newer technique called targeted muscle reinnervation (TMR), whi…

This study is testing whether a 16-week program of aerobic exercise or cognitive behavioral therapy (a type of talk therapy) can reduce severe fatigue in people with myasthenia gravis. It will involve 60 participants who will be randomly assigned to one of these programs or to co…

This study tests whether training primary care doctors in current insomnia treatment guidelines leads to better sleep for their patients. Researchers will compare sleep symptoms in patients whose doctors received this special training against patients whose doctors provide their …

This study aims to understand how patients with moderate mixed aortic valve disease fare compared to those with severe valve problems. Researchers will follow 1,900 patients to see if those with moderate disease might benefit from earlier valve repair or replacement surgery. The …

This study is testing whether a smartwatch-like device can be used to monitor people at home for a year after they leave the intensive care unit (ICU). The goal is to see if this technology is practical for patients to use and if it can collect useful health data. The study invol…

This international registry aims to gather real-world information on how a class of drugs called SGLT2 inhibitors is being used in adults born with heart defects. It will track 400 patients who are already prescribed this medication to see how they tolerate it and if it helps imp…

This study aims to use artificial intelligence (AI) to make a minimally invasive liver cancer treatment called thermal ablation more effective and accessible. Researchers will collect data from 1500 patients to develop AI tools that help doctors better select patients, plan treat…

This study aims to find better ways to predict when a critically ill patient in the ICU is ready to breathe on their own after using a ventilator. Researchers will test a new, non-invasive sensor that measures muscle activity and oxygen use during a short breathing test. The goal…

This study aims to understand how specific cells in a patient's immune system relate to survival in ovarian cancer. Researchers will collect blood and tissue samples from 300 patients before and during their standard treatments. The goal is to identify biological markers that cou…

This study is testing a new, simpler way to monitor cancer drug levels in the blood. It aims to validate a finger-prick test that patients can use at home, which could help doctors personalize drug doses more easily. The goal is to see if this method works as well as standard blo…

This study is testing whether smartphone recordings can help measure key symptoms of myasthenia gravis, a rare autoimmune disease that causes muscle weakness. Researchers will use video and audio from participants' phones to track symptoms like speech changes, eyelid drooping, an…

This study aims to understand why older adults lose important immune cells (T cells) in their noses and how this makes them more vulnerable to lung infections like pneumonia. Researchers will compare nasal and blood samples from 170 people across three groups: young adults, healt…