Leiden University Medical Center

This study is testing whether improving sleep or stimulating a neck nerve can help the brain's natural cleaning system remove harmful amyloid proteins in people with cerebral amyloid angiopathy (CAA). Sixty participants with different types of CAA will receive either a sleep medi…

This study is testing whether a new, proactive, and coordinated care model is better and more cost-effective than usual care for patients with multiple, complex health and social problems. It involves 200 patients across 20 primary care clinics who will receive a team-based appro…

This study is testing a two-part treatment for advanced eye (uveal) melanoma that has spread, mainly to the liver. It combines a liver-targeted chemotherapy procedure with two immunotherapy drugs given into the bloodstream. The goal is to see if this combination can better contro…

This study aims to find the best personalized treatment plan for people who have had their first dangerous blood clot (like a deep vein thrombosis or pulmonary embolism). Researchers will use a simple cheek swab and questionnaire to estimate each patient's risk of having another …

This study aims to understand how reduced blood flow in the brain's small vessels relates to Alzheimer's disease progression over time. Researchers will follow 120 older adults, including healthy controls and people with early memory problems, for three years using MRI scans and …

This study is testing a personalized computer tool called PERSARC. It helps patients with aggressive soft-tissue sarcoma in their arms or legs understand the risks and benefits of their treatment options. The goal is to see if using this tool helps patients feel more confident an…

This study aims to learn if the collection of bacteria in a patient's body (the microbiome) can help predict who will benefit from a specific lung cancer immunotherapy drug called durvalumab, or who might experience severe side effects. Researchers will collect stool, throat swab…

This study aims to understand the role of brain inflammation in frontotemporal lobar degeneration, a group of rare brain diseases that cause dementia. Researchers will use advanced brain scans, blood tests, and spinal fluid analysis in 110 participants, including patients and hea…