One size Doesn't fit all: new trial tests tailored blood thinners for joint replacement patients

NCT ID NCT06581965

Recruiting now Disease control Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients can reduce both clots and bleeding. Over 10,000 adults scheduled for joint replacement will be randomly assigned to either standard or personalized treatment and followed for three months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: blood thinners (LMWH or DOACs)
What this could lead to: If successful, this could show that customizing blood thinner treatment after joint replacement lowers the risk of both dangerous clots and bleeding complications.
What could go wrong: This is a large Phase 4 trial, but individualizing treatment may still fail to improve outcomes or could increase risks in some patients. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VEIN THROMBOSIS PULMONARY EMBOLISM VENOUS THROMBOEMBOLISM VENOUS THROMBOSES

Contacts and locations

Locations

Alrijne
RECRUITING

Leiderdorp, South Holland, 2353 GA, Netherlands
Anna Ziekenhuis
RECRUITING

Geldrop, North Brabant, 5564EH, Netherlands
Bergman Clinics
RECRUITING

Naarden, North Holland, 1411DE, Netherlands
Bravis ziekenhuis
NOT_YET_RECRUITING

Roosendaal, North Brabant, 4708 AE, Netherlands
Elisabeth-TweeSteden Ziekenhuis
RECRUITING

Tilburg, North Brabant, 5022GC, Netherlands
Gelre Ziekenhuizen
RECRUITING

Apeldoorn, Gelderland, 7334 DZ, Netherlands
Isala ziekenhuis
RECRUITING

Zwolle, Overijssel, 8025AB, Netherlands
OLVG
RECRUITING

Amsterdam, North Holland, 1091AC, Netherlands
Reinier Haga Orthopedisch Centrum
RECRUITING

Zoetermeer, South Holland, 2725NA, Netherlands
Zuyderland
RECRUITING

Geleen, Limburg, 6162 BG, Netherlands

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