DEEP VEIN THROMBOSIS

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This study compares two medical devices used to remove large blood clots from the leg veins. About 180 adults with acute deep vein thrombosis (DVT) will receive either the ClotTriever System or an aspiration device. The goal is to see which device clears clots better and reduces …

This study follows 82 people who receive the Celect Platinum Vena Cava Filter, a device placed in a large vein to catch blood clots and prevent them from reaching the lungs. Researchers will track safety and performance for up to 5 years, checking for problems like filter movemen…

This study tests whether a specially adjusted dose of the blood thinner apixaban can safely treat blood clots in cancer patients who also have low platelet counts. About 30 adults with active cancer and a recent clot will receive the adjusted dose. The goal is to see if this appr…

This study looks at 200 people who had a bleeding stroke caused by high blood pressure. Doctors want to know if starting blood thinners (heparin) early—within 2 days—or waiting until day 3 is safer and better at preventing blood clots in the legs or lungs. Participants get brain …

This study tests a new approach to remove blood clots from deep leg veins in people with acute deep vein thrombosis (DVT). The standard method accesses the vein behind the knee, while the new method uses veins in the calf or the opposite leg. Researchers want to see if the new ap…

This study tests whether taking a blood thinner (rivaroxaban) plus aspirin after a vein-stenting procedure keeps the vein open longer and prevents new clots. About 172 people with deep vein thrombosis and narrowed iliac veins will receive the combination for 6 months (rivaroxaban…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This trial tests whether doing ultrasound scans twice a week on critically ill patients can catch deep-vein thrombosis (DVT) early. The goal is to prevent pulmonary embolism (a clot in the lung) and reduce deaths within 90 days. The study will enroll 1,800 adults in the ICU who a…

This study tests a new, non-invasive way to measure blood flow in the legs of people who may have deep vein thrombosis (a blood clot). Researchers will use an air-filled bladder under a compression cuff to see how well blood moves. The goal is to improve detection of clots withou…