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Could a daily pill replace painful shots for leg injury patients?

NCT ID NCT06195540

Recruiting now Disease control Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and followed for 90 days. The goal is to see if the pill is at least as effective and easier for patients to use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Rivaroxaban (a blood-thinning pill)
What this could lead to
If it works, patients with leg trauma could take a simple daily pill instead of daily injections to prevent dangerous blood clots, improving convenience and comfort.
What could go wrong
This is a large phase 3 trial, but it's comparing two existing drugs, so it's not a breakthrough. There is a risk of bleeding with any blood thinner, and the study may not show a clear advantage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Emergencies injury pulmonary embolism Venous Thrombosis venous thromboembolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VEIN THROMBOSIS IMMOBILISATION LOWER LIMB TRAUMA PULMONARY EMBOLISM THROMBOPROPHYLAXIS VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

  • Agen-Nerac Hospital, Emergency Department

    ACTIVE_NOT_RECRUITING

    Agen, 47923, France

  • Angers University Hospital, Emergency department

    RECRUITING

    Angers, 49000, France

  • Argenteuil hospital, Emergency department

    RECRUITING

    Argenteuil, 95100, France

  • Arpajon Hospital, Emergency Department

    WITHDRAWN

    Arpajon, 91294, France

  • Bichat Hospital, Adult Emergency department

    RECRUITING

    Paris, 75018, France

  • Caen University hospital, Emergency department

    WITHDRAWN

    Caen, 14000, France

  • Cholet Hospital, Emergency department

    RECRUITING

    Cholet, 49300, France

  • Clermont-Ferrand University Hospital, Emergency department

    RECRUITING

    Clermont-Ferrand, 63000, France

  • Cochin Hospital, Emergency department

    RECRUITING

    Paris, 75014, France

  • Edouard Herriot University Hospital, Emergency Department

    RECRUITING

    Lyon, 69000, France

  • Eure-Seine Hospital, Emergency Departement

    ACTIVE_NOT_RECRUITING

    Évreux, 27015, France

  • Grenoble University Hospital, Emergency Department

    RECRUITING

    Grenoble, 38000, France

  • HEGP, Emergency Department

    RECRUITING

    Paris, 75015, France

  • La Pitié-Salpétrière Hospital, Emergency Department

    NOT_YET_RECRUITING

    Paris, 75013, France

  • La Roche sur Yon Hospital

    NOT_YET_RECRUITING

    La Roche-sur-Yon, 85000, France

  • La Rochelle Hospital, Adult emergency departement

    RECRUITING

    La Rochelle, 17000, France

  • Lariboisière hospital, emergency department

    NOT_YET_RECRUITING

    Paris, 75010, France

  • Le Mans Hospital, Emergency department

    RECRUITING

    Le Mans, 72000, France

  • Limoges University hospital, Emergency department

    RECRUITING

    Limoges, 87000, France

  • Marseille University Hospital, Emergency department

    RECRUITING

    Marseille, 13005, France

  • Melun Hospital, Emergency Department

    RECRUITING

    Melun, 77000, France

  • Montpellier University Hospital, emergency department

    RECRUITING

    Montpellier, 34000, France

  • Nancy University Hospital, Emergency department

    NOT_YET_RECRUITING

    Nancy, 54000, France

  • Nantes University Hospital, Emergency department

    RECRUITING

    Nantes, 44000, France

  • Nice University Hospital, Emergency department

    WITHDRAWN

    Nice, 06000, France

  • Niort Hospital, Emergency Department

    RECRUITING

    Niort, 79000, France

  • Poitiers University Hospital, Emergency department

    RECRUITING

    Poitiers, 86000, France

  • Rennes University Hospital, Emergency department

    RECRUITING

    Rennes, 35000, France

  • Rouen University Hospital, Emergency Department

    NOT_YET_RECRUITING

    Rouen, 76000, France

  • Saint-Antoine Hospital, Emergency department

    RECRUITING

    Paris, 75012, France

  • Simone Veil Hospital, Emergency Department

    RECRUITING

    Eaubonne, 95600, France

  • South Lyon University Hospital, Emergency department

    RECRUITING

    Pierre-Bénite, 69495, France

  • St-Joseph Hospital, Emergency Department

    RECRUITING

    Paris, 75014, France

  • Strasbourg University Hospital, Emergency Department

    RECRUITING

    Strasbourg, 67000, France

  • Toulouse University Hospital, Emergency Department

    RECRUITING

    Toulouse, 31000, France

  • Tours University Hospital, Emergency department

    WITHDRAWN

    Chambray-lès-Tours, 37170, France

  • Vannes Hospital, Emergency Department

    RECRUITING

    Vannes, 56000, France

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