VENOUS THROMBOEMBOLISM

This study tests whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinners can lower the risk of another blood clot in people who recently had a deep vein thrombosis or pulmonary embolism. About 2700 adults will receive either rosuvastatin or a p…

This study aims to see if giving blood thinners based on a person's individual risk—rather than a standard dose for everyone—can lower the chance of dangerous blood clots and bleeding after hip or knee replacement. About 10,000 adults scheduled for joint replacement will be assig…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can reduce the risk of post-thrombotic syndrome (long-term leg pain and swelling) after a deep vein thrombosis (DVT). The trial will enroll 150 adults with a first DVT to see if it's possible to r…

This study compares two blood thinners—rivaroxaban (a pill) and low-molecular-weight heparin (a daily injection)—in people with leg injuries that require a cast or brace for at least two weeks. The goal is to see if the pill is as good as or better than the injection at preventin…

This study is testing two medical devices, Symphony and Prodigy, that remove blood clots from arteries, veins, or the lungs. About 750 adults who need a clot-removal procedure will be followed to see if the devices safely restore blood flow and prevent serious problems like amput…

This study tests a drug called Kinisoquin to see if it can prevent dangerous blood clots in people with advanced pancreatic cancer. About 480 adults with metastatic or locally advanced pancreatic cancer who are starting chemotherapy will receive either Kinisoquin or a placebo. Th…

This study looks at a new way to decide how long people with unexplained blood clots should take blood thinners. Currently, many patients take these drugs indefinitely, which can raise the risk of serious bleeding. The researchers will use special risk scores and involve patients…

This study tests whether a device that physically removes blood clots from the leg works better than standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 adults with a recent, severe clot in one leg will be randomly assigned to either the…

This study follows 82 people who receive a vena cava filter to prevent blood clots from reaching the lungs. The filter is placed in a large vein to catch clots. Researchers will check for complications like filter movement or breakage and how well the filter works over up to 5 ye…

This study tests whether a pill (apixaban) is a safe and easier alternative to daily shots (enoxaparin) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery. Researchers will check for side eff…

This study tests whether omeprazole, a common stomach acid drug, can reduce gastrointestinal bleeding in adults aged 65 and older who are taking blood thinners for a blood clot. The study will enroll 360 participants to see if a larger trial is feasible. It focuses on safety and …

This study tests a new drug called SRSD107 to prevent blood clots in adults aged 60-80 having knee replacement surgery. About 450 participants will receive either SRSD107 or a standard blood thinner, enoxaparin, for up to 28 days before surgery. The goal is to see which dose work…

This study tests whether a computer alert can help doctors remember to prescribe blood clot prevention medicine for high-risk patients when they leave the hospital. About 400 adults aged 40 and older with serious medical conditions will take part. The goal is to see if the alert …

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study tests whether the blood thinner apixaban can safely prevent blood clots in people with newly diagnosed grade 4 glioma (a type of brain cancer). About 40 participants will take apixaban while receiving standard radiation and chemotherapy. The main goal is to check for b…

This study looks at whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 6,660 adults having keyhole vein procedures will be randomly assigned to receive either the medicine or a placebo. The goal is to s…

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after high-risk surgeries like cancer or joint replacement. About 8,600 adults having elective surgery will …

This study looks at the best time to start blood thinners (heparin) in people who have had a brain bleed due to high blood pressure. The goal is to prevent dangerous blood clots in the legs or lungs without causing more bleeding in the brain. About 200 participants will be random…

This study tests a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in cancer patients. About 259 people who have had a clot and completed 3-12 months of blood thinners will join. The goal is to see if a low-risk DNA result means it's s…

This study looks at 380 cancer patients getting chemotherapy to find out who is most likely to develop a dangerous blood clot. Researchers will measure clotting-related substances in the blood at four points during treatment. The goal is to create a blood test that can predict cl…

This study looks at whether a computer program that helps doctors make decisions can improve how often patients with traumatic brain injury get the right treatment to prevent blood clots. About 15,000 adults across 7 hospitals will take part. The goal is to see if the tool increa…

This study tests whether a hospital-wide quality improvement program can increase the use of blood clot prevention methods (like blood thinners or compression devices) in hospitalized patients. About 5,800 adults across multiple hospitals in China will take part. The goal is to s…

This study tests whether a scoring system called Caprini can accurately predict blood clots after varicose vein surgery. Researchers will follow 3,000 adults for 4 weeks after their procedure to see who develops clots. The goal is to identify high-risk patients who would benefit …

This study is a registry that collects information from adults who are already scheduled to have an IVC filter placed or removed. The goal is to track their health over time to better understand the long-term effects and safety of these filters. No new treatments or procedures ar…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study is a large registry that collects information from patients with venous thromboembolism (blood clots in veins). It aims to help doctors better understand the disease and improve care, especially for groups often left out of other studies, like pregnant women and the el…

This study follows 825 pregnant women who need blood thinners for blood clots. Researchers will track how doctors manage these medications around childbirth and the weeks after. The goal is to find the safest approach to prevent bleeding while protecting mother and baby.

This observational study tracks 2,400 lung cancer patients treated with immune checkpoint inhibitors to understand how often blood clots (in veins or arteries) occur and what raises that risk. Researchers will compare patients who develop clots with those who don't, looking for b…

This study is not testing a new drug or treatment. Instead, researchers are combining medical information from 14 different European groups that have studied blood clots (venous thromboembolism). By pooling data from about 20,000 people, they hope to better predict who is at risk…