Could a cholesterol drug stop blood clots from coming back?

NCT ID NCT04319627

Recruiting now Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive either rosuvastatin or a placebo pill alongside their usual care. The goal is to see if the statin reduces recurrent clots and helps prevent long-term vein damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rosuvastatin (a cholesterol-lowering statin drug)
What this could lead to: If it works, this could show that adding a common statin to standard blood thinners helps prevent future blood clots and reduces long-term vein damage.
What could go wrong: This is a large phase 3 trial, but statins are not yet proven for this use. The benefit may be small or absent, and statins can cause muscle pain or rare liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

post-thrombotic syndrome Postthrombotic Syndrome pulmonary embolism thrombotic disease venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD CLOT POST THROMBOTIC SYNDROME VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

APHP Hôpital Louis Mourier
RECRUITING

Colombes, France
Aberdeen Royal Infirmary
NOT_YET_RECRUITING

Aberdeen, United Kingdom
Brest University Hospital Centre
RECRUITING

Brest, France
CHI Toulon - La Seyne sur Mer - Hôpital Sainte Musse
RECRUITING

Toulon, France
CHU d'Angers - Service d'accueil et traitement des Urgences
RECRUITING

Angers, France
CHU de Clermont-Ferrand, Hôpital Gabriel Montpied
RECRUITING

Clermont-Ferrand, France
CHU de Dijon - Service d'imagerie diagnostique et thérapeutique
RECRUITING

Dijon, France
CHU de Quebec-Université Laval
RECRUITING

Québec, Quebec, G1V 4G2, Canada
CIUSSS de-l'Ouest-de-l'Ile-de-Montreal -St. Mary's Hospital Center
RECRUITING

Montreal, Quebec, H9R 2Y2, Canada
Centre Hospitalier Universitaire De Saint Etienne
RECRUITING

Saint-Etienne, France
Foothills Medical Centre
RECRUITING

Calgary, Alberta, T2N 2T9, Canada
GH La Rochelle - Ré-Aunis - Service de Médecine vasculaire
RECRUITING

La Rochelle, France
Glasgow Royal Infirmary
NOT_YET_RECRUITING

Glasgow, United Kingdom
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Hôpital Montfort
WITHDRAWN

Ottawa, Ontario, K1K 0T2, Canada
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Juravinski Hospital
WITHDRAWN

Hamilton, Ontario, L8V 1C3, Canada
King's College Hospital NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom
Mater Misericordiae University Hospital
NOT_YET_RECRUITING

Dublin, Ireland
McGill Univeristy Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Niagara Health - St. Catharines Site
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
Ostfold Hopsital
RECRUITING

Sarpsborg, Norway
Oxford University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Oxford, United Kingdom
Queen Elizabeth Hospital
NOT_YET_RECRUITING

Birmingham, United Kingdom
Queen Elizabeth II Hospital
WITHDRAWN

Halifax, Nova Scotia, B3H 2Y9, Canada
St. Joseph's Healthcare
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
Sunnybrook Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M4N 3M5, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
University Hospital of Wales
NOT_YET_RECRUITING

Cardiff, United Kingdom
University of Insubria
NOT_YET_RECRUITING

Varese, Italy

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