Ottawa Hospital Research Institute

This study is testing whether removing nasal polyps in a doctor's office works as well as traditional sinus surgery done in a hospital operating room. Researchers want to see if the simpler office procedure provides similar symptom relief while costing much less and having shorte…

This early-stage study is testing whether a non-invasive laser treatment can safely reduce penile curvature caused by Peyronie's disease. The trial will enroll 60 men with stable, chronic Peyronie's disease to receive three laser sessions. Researchers will monitor safety and see …

This large Phase 3 trial is testing whether adding the cholesterol-lowering drug rosuvastatin to standard blood thinners can help prevent dangerous blood clots from returning. The study will enroll 2,700 adults who recently had a major leg or lung clot, giving half the participan…

This study aims to find out if adding a minimally invasive 'scope' procedure during a major hip realignment surgery leads to better results. It will compare the standard surgery (PAO) to the standard surgery plus the scope procedure in about 200 patients aged 16-50 with hip dyspl…

This study is testing if a low daily dose of colchicine, an anti-inflammatory drug, can prevent a painful long-term condition called post-thrombotic syndrome (PTS) after a serious leg blood clot (DVT). It will involve 150 adults who have just been diagnosed with a DVT. Participan…

This pilot study aims to determine if it's practical to conduct a larger trial comparing two delivery timing approaches for people with gestational diabetes. Researchers will recruit 260 pregnant individuals in Canada and randomly assign them to either have labor induced at 38 we…

This large study is comparing two strategies to prevent serious bleeding in adults with blood cancer who are receiving a stem cell transplant using their own cells. One group gets the current standard of routine platelet transfusions when counts are low. The other group gets a co…

This study is testing whether the time of day a brain cancer patient takes their chemotherapy pill matters. Researchers want to see if taking the drug, temozolomide, in the morning or evening is easier for patients to stick to and if it affects their quality of life or outcomes. …

This study is testing whether adding naturopathic doctor-guided care—including personalized diet, supplements, and lifestyle advice—to standard cancer surgery helps patients recover better. It aims to reduce complications, improve quality of life, and potentially help patients li…

This study aims to find out which of two newer blood thinners, apixaban or rivaroxaban, causes fewer bleeding problems in people with atrial fibrillation (AFib). It will enroll over 3,000 adults newly diagnosed with AFib who need to start a blood thinner to prevent strokes. The g…

This pilot study is testing whether the time of day people take their hormone-based cancer drugs makes a difference. It will enroll 50 people with metastatic breast or prostate cancer and randomly assign them to take their medication either in the morning or the evening. The main…

This study is testing a new treatment plan for a serious autoimmune disease that attacks the kidneys. It compares a much shorter, lower-dose course of steroids (4 weeks) against the current standard treatment (6+ months) to see if it works just as well. The main goal is to see if…

This study aims to see if finding and treating people with undiagnosed asthma or COPD early can make them feel better. Researchers will use an online questionnaire to find adults with breathing symptoms but no diagnosis. Those likely to have asthma or COPD will join a trial where…

This study is testing if sending fainting patients home from the emergency room with a 15-day heart monitor can find dangerous heart rhythms better than standard care. It will involve 580 adults across Canada who are at medium or high risk for heart problems. The goal is to see i…

This study is testing if a common heartburn medicine called omeprazole can prevent stomach and intestinal bleeding in adults 65 and older who are taking blood thinners for a recent blood clot. It's a pilot study to see if a larger trial is possible. Some participants will get ome…

This small, early study is exploring whether using a vacuum erection device daily for six months is a practical and acceptable approach for men experiencing penile numbness. It will enroll eight men to see if they can stick with the daily routine and complete the required check-i…

This study is testing if breast cancer patients can safely skip a standard injection (G-CSF) during part of their chemotherapy. The injection helps prevent infection but often causes severe bone pain. Researchers want to see if skipping it reduces pain and improves quality of lif…

This study is testing if a medication called modafinil can help reduce severe fatigue and thinking problems (often called 'chemo brain') in people with advanced cancer. About 40 patients will take either the drug or a placebo pill for one week to see if it makes a difference. The…

This study aims to understand why some people remain unhappy after knee replacement surgery despite the procedure being generally successful. Researchers will use MRI brain scans taken before surgery to look for patterns in brain activity that might predict which patients will ex…