Ottawa Hospital Research Institute

This study tests whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinners can lower the risk of another blood clot in people who recently had a deep vein thrombosis or pulmonary embolism. About 2700 adults will receive either rosuvastatin or a p…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can reduce the risk of post-thrombotic syndrome (long-term leg pain and swelling) after a deep vein thrombosis (DVT). The trial will enroll 150 adults with a first DVT to see if it's possible to r…

This study tests whether a shorter, lower-dose steroid course (4 weeks) combined with standard medications is as safe and effective as the usual longer steroid treatment for people with ANCA vasculitis and severe kidney problems. The goal is to reduce serious infections while sti…

This study compares two common blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults with newly diagnosed AF will be randomly assigned to one of the two drugs. The goal is to hel…

This study tests if removing nasal polyps in a doctor's office works as well as surgery in a hospital operating room for people with chronic sinusitis. About 140 adults with nasal polyps will be randomly assigned to one of the two treatments. The goal is to see if the cheaper, fa…

This study tests whether omeprazole, a common stomach acid drug, can reduce gastrointestinal bleeding in adults aged 65 and older who are taking blood thinners for a blood clot. The study will enroll 360 participants to see if a larger trial is feasible. It focuses on safety and …

This study tests whether a medicine called tranexamic acid (TXA) can safely replace routine platelet transfusions to prevent bleeding in adults receiving a stem cell transplant for blood cancer. About 662 participants will be randomly assigned to receive either TXA with platelet …

This study tests whether a home-based exercise program done before surgery can reduce disability and improve recovery. About 900 adults scheduled for major surgery will either follow the virtual training or receive usual care. The goal is to see if getting fitter before an operat…

This study looks at whether taking the chemotherapy drug temozolomide in the morning or evening is practical for people with glioblastoma, a type of brain cancer. About 50 adults who have already had surgery and radiation will be randomly assigned to take their medication either …

This small study is testing whether using a vacuum erection device every day for six months can help men who have lost feeling in their penis. Eight adult men with penile numbness will use the device at home and report their experiences through questionnaires. The goal is to see …

This early-stage study tests whether a fractional CO2 laser can safely reduce the penile curvature caused by Peyronie's disease. Sixty men with stable disease for at least a year will receive three laser sessions six weeks apart. The main goal is to check for side effects, while …

This study looks at whether women with early-stage breast cancer can safely skip a drug called G-CSF during one part of their chemotherapy to reduce bone pain. About 242 participants will be randomly assigned to either take or skip the drug while on paclitaxel. The main goal is t…

This study tests a personalized program of diet, exercise, supplements, and stress management for people undergoing surgery for lung, stomach, or esophageal cancer. The goal is to see if this approach improves quality of life, reduces complications, and helps patients feel better…

This study looks at whether adding hip arthroscopy to a standard PAO surgery improves recovery and quality of life for people with hip dysplasia. About 204 participants aged 16-50 will be randomly assigned to receive either PAO alone or PAO plus arthroscopy. The goal is to find o…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study looks at how well people with type 2 diabetes can produce insulin after drinking a meal replacement shake. Researchers will take blood samples over two hours to measure insulin and blood sugar levels. The goal is to understand differences in insulin production and how …

Knee replacement helps many, but 1 in 5 patients still have pain or trouble moving after surgery. This study looks at brain scans (MRI) before and after surgery to see if certain brain patterns can predict who will be satisfied. Researchers hope to find brain markers that help do…

This study looks at whether taking endocrine therapy in the morning or evening makes a difference for people with metastatic breast or prostate cancer. About 50 participants will be randomly assigned to take their medication at one of these times. The main goal is to see if a lar…

This study looks at whether a simple test measuring heart and breathing patterns before major chest surgery can help predict complications after the operation. Researchers will enroll 130 adults undergoing surgery for lung, esophageal, or stomach cancer. The goal is to see if thi…

This study tests a computer tool called the Extubation Advisor that helps doctors decide when to safely remove a breathing tube from critically ill patients. About 200 adults on ventilators for more than 48 hours will take part. The tool combines patient data with doctor assessme…

This study looks at whether inducing labor at 38 weeks of pregnancy is a good idea for people with gestational diabetes. It compares early induction to waiting for labor to start naturally. The goal is to see if a larger study is possible, not to find a cure. About 260 pregnant p…

This study tests whether a 15-day remote heart monitor can find dangerous heart rhythms in people who fainted and were sent home from the emergency room. About 580 adults at medium or high risk will be randomly assigned to the monitor or usual care. The goal is to see if longer m…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their primary care doctor or usual ca…