Ottawa Hospital Research Institute

This small pilot study aimed to see if a larger trial comparing two newer blood thinners (rivaroxaban and apixaban) for treating serious blood clots was possible. It enrolled 72 adults with newly diagnosed clots in their legs or lungs. The main goal was to test the process for a …

This study directly compared two different surgical mesh materials used to support breast implants during reconstruction surgery after mastectomy. Researchers wanted to see if a less expensive mesh performed as well as a more expensive one in terms of healing, complications, and …

This trial aimed to find the best schedule for giving zoledronate, a drug that strengthens bones and may help prevent cancer from spreading there. It compared giving just one dose versus giving a dose every six months for three years to over 200 patients with early-stage breast c…

This study tested whether paramedics could use a simple checklist (the Canadian C-Spine Rule) to decide which trauma patients with possible neck injuries need to be transported with full spinal immobilization. It involved over 3,600 patients across Ontario and aimed to reduce unn…

This study directly compared two common blood thinners, apixaban and rivaroxaban, to see which causes fewer serious bleeding problems when treating dangerous blood clots in the legs or lungs. Over 2,700 adults with newly diagnosed clots participated in this real-world trial. Rese…

This small pilot study explored whether two non-drug therapies could help people hospitalized for manic episodes of bipolar disorder. Researchers tested if restricting eating to a 10-hour daytime window and/or wearing glasses that block blue light could improve manic symptoms and…

This study compared two different follow-up care plans for people who had finished their main breast cancer treatment. It tested whether a personalized schedule, potentially with fewer clinic visits, was as good as a standard guideline-based schedule. The main goal was to see if …

This study tested a set of questions and a blood test (a 'clinical decision rule') to help doctors more accurately diagnose a new blood clot in patients who have had one before. It involved 744 adult outpatients who were suspected of having a repeat clot. The goal was to see if t…

This study tested whether a patient portal app called MyChart could be used to help find the best ways to manage hot flashes caused by breast cancer treatments. Researchers enrolled 56 breast cancer patients experiencing hot flashes to see if they could use the app to track their…

This study aimed to find the best time of day to take hormone therapy pills for breast cancer to reduce side effects and help patients continue their treatment. Researchers compared taking the medication in the morning versus the evening in 245 patients with early-stage breast ca…

This study tested whether an online training program before surgery helps patients recover better. 144 adults scheduled for major operations were randomly assigned to either follow the online program or receive usual care. The program included guided exercise, nutrition advice, a…

This study aimed to find the best schedule for checking heart health in patients receiving trastuzumab, a life-saving breast cancer drug that can sometimes weaken the heart. Researchers compared two different standard monitoring plans in 200 patients with early-stage breast cance…

This study observed whether giving doctors access to free online prediction tools changed how often they ordered an expensive genetic test (Oncotype DX) for patients with early-stage breast cancer. Researchers tracked 602 patients and surveyed their doctors to understand decision…