Could a single Bone-Strengthening shot be enough for breast cancer patients?
NCT ID NCT03664687
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a single dose of the bone drug zoledronate works as well as doses given every six months for three years in women with early-stage breast cancer. The goal was to see if a simpler schedule is feasible and could reduce side effects. The trial enrolled 211 patients and measured how quickly study sites could recruit participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
zoledronate (zoledronic acid)
What this could lead to
If a single dose works as well as multiple doses, it could simplify treatment and reduce side effects for early-stage breast cancer patients.
What could go wrong
This is a small, early-phase trial focused on feasibility, not on proving the single dose is equally effective. The single dose may not protect against bone metastases as well as the standard schedule.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Juravinski Cancer Centre
Hamilton, Ontario, L8V 5C2, Canada
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Kingston Health Sciences Centre
Kingston, Ontario, K7L 2V7, Canada
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Markham Stouffville Hospital
Markham, Ontario, L3P 7P3, Canada
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Ottawa Hospital Research Institute
Ottawa, Ontario, K1H 8M2, Canada
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Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2P9, Canada
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William Osler Health System, Brampton Civic Hospital
Brampton, Ontario, L6R 3J7, Canada