Could a single Bone-Strengthening shot be enough for breast cancer patients?

NCT ID NCT03664687

Completed Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tested whether a single dose of the bone drug zoledronate works as well as doses given every six months for three years in women with early-stage breast cancer. The goal was to see if a simpler schedule is feasible and could reduce side effects. The trial enrolled 211 patients and measured how quickly study sites could recruit participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zoledronate (zoledronic acid)
What this could lead to: If a single dose works as well as multiple doses, it could simplify treatment and reduce side effects for early-stage breast cancer patients.
What could go wrong: This is a small, early-phase trial focused on feasibility, not on proving the single dose is equally effective. The single dose may not protect against bone metastases as well as the standard schedule.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY-STAGE BREAST CANCER

Contacts and locations

Locations

Juravinski Cancer Centre

Hamilton, Ontario, L8V 5C2, Canada
Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada
Markham Stouffville Hospital

Markham, Ontario, L3P 7P3, Canada
Ottawa Hospital Research Institute

Ottawa, Ontario, K1H 8M2, Canada
Southlake Regional Health Centre

Newmarket, Ontario, L3Y 2P9, Canada
William Osler Health System, Brampton Civic Hospital

Brampton, Ontario, L6R 3J7, Canada

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