EARLY-STAGE BREAST CANCER

This study is testing whether adding cholesterol-lowering statin drugs can protect the heart in patients receiving targeted therapy for early-stage HER2-positive breast cancer. Researchers want to see if statins reduce treatment delays or early stops caused by heart side effects.…

This study is testing whether a shorter, 5-session radiation treatment is safe and effective for women with early-stage breast cancer. Researchers want to see if this condensed schedule controls cancer recurrence while causing acceptable side effects and maintaining good quality …

This study compares two different drug combinations to see which works better at preventing breast cancer from coming back after initial treatment. It's for women with a specific type of breast cancer (HER2-positive) who still have a small amount of cancer after their first round…

This study is testing a newer targeted drug called trastuzumab deruxtecan, given alone or with a hormone-blocking pill (anastrozole), before surgery for early-stage breast cancer. The goal is to see which approach is better at shrinking or eliminating the tumor. It is for people …

This study is testing a very short, 5-session radiation treatment for women with early-stage breast cancer. It aims to see how well the treatment works, how it affects the breast's appearance, and what side effects patients experience. Researchers will follow 50 participants for …

This study is testing a personalized approach to reduce chemotherapy for women with a common type of early-stage breast cancer. It uses a simple blood test to see if a targeted pill (dalpiciclib) combined with hormone therapy works as well as standard chemo before surgery. The go…

This trial aims to find the best drug combinations for different types of breast cancer before surgery. It tests new drugs alongside standard chemotherapy in 5,000 women with early-stage or locally advanced breast cancer. The study uses tumor analysis and MRI scans to match treat…

This study is testing whether a 6-month exercise program can help prevent breast cancer from returning in survivors. It will involve over 2,100 women who have completed surgery and other treatments. Participants will either follow a supervised exercise plan or be observed, to see…

This study is testing if a short course of a low-dose drug called azacitidine, given before surgery, can help the body's own immune cells better attack high-risk, early-stage breast cancer tumors. Researchers will measure changes in immune cells within the tumor and see if the tr…

This study is testing whether a diagnostic tool called HER2DX can help doctors choose the best treatment for people with early-stage HER2-positive breast cancer. About 304 participants will be randomly assigned to receive either standard treatment or treatment guided by the HER2D…

This study is testing if breast cancer patients can safely skip a standard injection (G-CSF) during part of their chemotherapy. The injection helps prevent infection but often causes severe bone pain. Researchers want to see if skipping it reduces pain and improves quality of lif…

This study aims to find the most effective aerobic exercise program to improve heart and lung fitness in women who have completed treatment for early-stage breast cancer. Researchers will compare different amounts and durations of exercise to see which plan best helps participant…

This study aims to help breast cancer patients stay on their hormone therapy by better managing its side effects. Researchers will compare two approaches for women who develop bothersome symptoms: switching to a different medication versus following standard treatment guidelines.…

This study aims to see if a simple blood test can find tiny bits of leftover cancer DNA after treatment. Researchers will track 900 patients with early-stage breast cancer to see if this 'liquid biopsy' can predict if their cancer will come back. The goal is to gather knowledge t…