New drug combo shows promise for Hard-to-Treat breast cancer

NCT ID NCT04553770

First seen Nov 10, 2025 · Last updated Jun 16, 2026 · Updated 32 times

Summary

This study tests a drug called trastuzumab deruxtecan, which delivers chemotherapy directly to cancer cells, alone or with anastrozole (a hormone blocker), for people with early-stage HER2 low, hormone receptor positive breast cancer. The goal is to see if the cancer disappears completely before surgery. About 88 participants will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cancer Blood and Specialty Clinic

    RECRUITING

    Los Alamitos, California, 90720, United States

    Contact Phone: •••-•••-••••

    Contact

  • Cancer Center of Kansas

    RECRUITING

    Wichita, Kansas, 67214, United States

    Contact Phone: •••-•••-••••

    Contact

  • Ft. Wayne Medical Oncology and Hematology, Inc.

    WITHDRAWN

    Fort Wayne, Indiana, 46804, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-••••

    Contact

  • Orlando Health, Inc. d/b/a Orlando Health UF Health Center

    WITHDRAWN

    Orlando, Florida, 32806, United States

  • PIH Health

    RECRUITING

    Whittier, California, 90602, United States

    Contact Phone: •••-•••-••••

    Contact

  • St. Joseph Heritage Healthcare

    RECRUITING

    Fullerton, California, 92835, United States

    Contact Phone: •••-•••-••••

    Contact

  • Torrance Memorial Physician Network / Cancer Care

    RECRUITING

    Torrance, California, 90602, United States

    Contact Phone: •••-•••-••••

    Contact

  • UCLA / Jonsson Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90095, United States

    Contact

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

Conditions inferred from the trial description

These were inferred from the trial's summary, not listed by the trial registrant.