Gut bacteria may fortify bones in breast cancer therapy
NCT ID NCT07044310
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether a probiotic blend called WBF-038 can prevent bone loss in women with early-stage hormone receptor-positive breast cancer who are about to start aromatase inhibitor therapy. Aromatase inhibitors lower estrogen, which can weaken bones. The study will give participants the probiotic for a year and measure changes in bone turnover and density, along with blood sugar, weight, and waist size, to see if the probiotic helps maintain bone and metabolic health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A synbiotic formulation combining prebiotics and five probiotic strains, including Akkermansia muciniphila and Bifidobacterium infantis, designed to improve metabolic and bone health.
- What this could lead to
- If effective, this probiotic could offer a simple, non-drug way to protect bone health and reduce fracture risk in breast cancer patients on aromatase inhibitors.
- What could go wrong
- This is a small, early-phase trial, so results may not apply broadly. The probiotic may not significantly slow bone loss, and some people could experience digestive discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Mayo Clinic in Florida
RECRUITINGJacksonville, Florida, 32224-9980, United States
Contact Email: •••••@•••••
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