Digital therapy aims to tame the fear that haunts cancer survivors

NCT ID NCT07741968

Recruiting now Symptom relief Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This trial tests a blended e-health program designed to help women with breast or gynecologic cancer cope with fear of their cancer returning or worsening. The program combines remote group sessions with online modules that teach skills to manage unhelpful thoughts and promote helpful coping behaviors. Researchers will see if the program is feasible and acceptable, and whether it reduces fear of progression and related distress.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A blended e-health intervention combining remote group sessions and online modules to help manage fear of cancer progression.
What this could lead to: If effective, this program could offer a scalable, accessible way to reduce fear of cancer progression, improving emotional well-being and quality of life for many cancer survivors.
What could go wrong: This is an early feasibility study, so it may not show significant benefits. The intervention requires active participation, and dropout or low engagement could limit its impact.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm carcinosarcoma of the corpus uteri cervical cancer endometrial carcinoma endometrium neoplasm female reproductive organ cancer mixed epithelial/mesenchymal metaplastic breast carcinoma ovarian cancer ovarian carcinoma ovarian carcinosarcoma triple-negative breast carcinoma Uterine Cervical Neoplasms vaginal cancer vulva cancer vulvar carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE I BREAST CANCER AJCC V8 ANATOMIC STAGE II BREAST CANCER AJCC V8 ANATOMIC STAGE III BREAST CANCER AJCC V8 ANATOMIC STAGE IV BREAST CANCER AJCC V8 BREAST CARCINOMA BREAST MIXED EPITHELIAL/MESENCHYMAL METAPLASTIC CARCINOMA ENDOMETRIAL CARCINOMA MALIGNANT FEMALE REPRODUCTIVE SYSTEM NEOPLASM OVARIAN CARCINOMA OVARIAN CARCINOSARCOMA STAGE III CERVICAL CANCER AJCC V8 STAGE III VAGINAL CANCER AJCC V8 STAGE III VULVAR CANCER AJCC V8 STAGE IV CERVICAL CANCER AJCC V8 STAGE IV VAGINAL CANCER AJCC V8 STAGE IV VULVAR CANCER AJCC V8 TRIPLE-NEGATIVE BREAST CARCINOMA UTERINE CORPUS CARCINOSARCOMA

Contacts and locations

Locations

City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States
City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
City of Hope at Arcadia
RECRUITING

Arcadia, California, 91007, United States
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
City of Hope at Long Beach Elm
RECRUITING

Long Beach, California, 90813, United States
City of Hope at Santa Clarita
RECRUITING

Santa Clarita, California, 91355, United States
City of Hope at Seacliff
RECRUITING

Huntington Beach, California, 92648, United States
City of Hope at Simi Valley
RECRUITING

Simi Valley, California, 93065, United States
City of Hope at South Pasadena
RECRUITING

South Pasadena, California, 91030, United States
City of Hope at Upland
RECRUITING

Upland, California, 91786, United States
City of Hope at West Covina
RECRUITING

West Covina, California, 91790, United States

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