BREAST CARCINOMA

This study tests a new drug called GTAEXS617 in people with advanced solid tumors that have not responded to standard treatments. The goal is to check the drug's safety, how the body processes it, and whether it can shrink tumors. About 230 adults with certain cancers like lung, …

This study is for people with metastatic breast cancer whose disease has started to grow in just a few spots while on their current treatment. It tests whether using precise, high-dose radiation on those spots can allow them to keep using their current medication for at least 6 m…

This study tests a new, shorter radiation schedule for women with stage I-III breast cancer. Instead of the usual 3-4 weeks of daily radiation, this approach delivers the entire treatment in just 5 days. The goal is to see if this ultra-fast method is as effective at preventing c…

This study tests a new 3D ultrasound technology to see if it can better tell if lymph nodes in breast cancer patients are cancerous or not. About 55 adults who already need a lymph node biopsy or have a clip placed will get the 3D scan. The goal is to see if 3D ultrasound is more…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study tests a new breast ultrasound method to see if it can better detect breast cancer and measure how well treatment is working. Researchers at Mayo Clinic will enroll 550 adults with suspicious breast lumps or confirmed breast cancer. The goal is to improve diagnosis and …

This early-phase study tests a radioactive tracer called [18F]FTT to see if it can help PET/CT scans find more tumor cells in people with solid tumors, including ovarian, breast, and fallopian tube cancers. About 300 participants will receive the tracer and undergo imaging. The g…

This study tests whether a special ultrasound with contrast dye, combined with computer analysis, can accurately tell if a breast lump is harmless or cancerous. About 100 women with suspicious breast findings will get this imaging before their planned biopsy. The goal is to see i…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will look at medical records from 750 women to see which method is more accurate and reduces the need for extra tests. The goal is to …

This study tests a new imaging method called photoacoustic tomography that uses light and sound to get more detailed pictures of breast tissue. It aims to help find breast cancer in women with dense breasts, where standard mammograms may miss tumors. About 400 women with suspicio…

This study is testing whether a blood test, called a liquid biopsy, can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue diagnoses in about 490 women. If successful, this could offer a less invasive way to screen…

This study looks at whether a special type of mammogram called contrast-enhanced spectral mammography (CESM) can better find the cause of nipple discharge and detect breast cancer. CESM uses an injected dye to make tissues and blood vessels more visible. The goal is to see if CES…

This study looks at whether adding high-dose omega-3 fatty acids to low-dose tamoxifen can better reduce breast cancer risk in overweight postmenopausal women who are already at higher risk. Tamoxifen blocks estrogen, which can fuel some breast cancers, while omega-3s may help wi…

This study tests whether a low dose of tamoxifen can safely reduce breast density—a key risk factor for breast cancer—in premenopausal women at higher-than-average risk. About 200 women will receive a response-guided dose, with adjustments based on how their breast density change…

This study tests whether drinking tart cherry juice can help prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice daily …

This study tests whether taking low-dose aspirin can reduce inflammation and lower the risk of breast cancer in women who have given birth within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes in …

This study tests two drugs, acolbifene and low-dose tamoxifen, to see which works better at preventing breast cancer in premenopausal women at high risk. Both drugs block estrogen from fueling breast cell growth. About 80 women will take one of the drugs for six months, and resea…

This study tests whether using community advocates can increase the number of people who get screened for breast and lung cancer. Researchers will enroll 800 eligible adults and track how many complete their recommended screenings. The goal is to understand psychological barriers…

This study tests whether a comprehensive prevention program can reduce the risk of lymphedema (arm swelling) in women with breast cancer who have lymph nodes removed. About 285 participants will be followed for at least a year. The program focuses on helping lymph fluid drain pro…

This study tests whether a patient navigator—a guide who helps women understand their options—can improve how high-risk women manage their breast cancer risk. About 75 women with a family history of breast cancer but no personal diagnosis will receive support to make informed cho…

This study tests whether a connected platform (a special medication bag called WiseBag plus text reminders) helps people with metastatic breast cancer take their CDK4/6 inhibitor pills more consistently. About 410 patients will either use the bag alone or the bag with text alerts…

This study compares giving a shorter course of radiation (hypofractionated radiotherapy) before versus after breast surgery for people with early-stage breast cancer that hasn't spread. The goal is to see if giving radiation before surgery reduces side effects and treatment time …

This study tests a virtual mind-body program called Integrative Medicine at Home (IM@Home) for breast cancer patients undergoing radiation. The program includes online cardio and yoga classes to help reduce fatigue, depression, and other symptoms. Researchers want to see if patie…

This study tests whether cannabis-based compounds (CBD and THC) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 participants will receive different types of phytocannabinoids and report their symptoms ov…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. Researchers wa…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests a simple decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms, helps clarify treatment priorities, and prepares patients to discuss options with th…

This study tests whether a custom 3D-printed external breast prosthesis feels better and fits better than standard options for people who had a breast removed (mastectomy) but did not have reconstruction. About 50 adults will receive a personalized prosthesis made from a 3D scan …

This early study is testing whether a wearable headband that tracks brain activity can help breast cancer survivors manage anxiety and insomnia. About 40 survivors who have had breast cancer in the past 10 years and currently struggle with anxiety and poor sleep will use the MUSE…

This study tests two different walking programs for women with breast cancer who are getting chemotherapy. One program has a fixed amount of walking each week, while the other adjusts the walking amount based on how the person responds. The goal is to see which approach better im…

This study tests if doing breathing exercises at home can help reduce heart and lung side effects in people getting chemotherapy for breast cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for patients undergoing t…

This study tests whether a 14-day mobile daily diary is a practical way to measure daily stress and thinking (cognitive) performance in breast cancer survivors from different racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past t…

This study looks at tissue, mammograms, and genetics from 4500 women who had a benign breast biopsy to find clues about who might later develop breast cancer. The goal is to improve risk prediction and make future diagnosis and treatment more personalized. Participants must be fe…

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. Researchers want to see if tamoxifen causes these cells to produce too many NETs, which might lead to side effects. About 290 women with ER+ breast cancer who are taki…

This study examines DNA from 162 breast cancer patients who received chemotherapy and either did or did not develop congestive heart failure. Researchers are looking for rare genetic changes that might increase the risk of heart failure after treatment. The goal is to better unde…

This study looks at hair loss in women with breast cancer who are taking hormone therapy (endocrine therapy). While hair loss is a known side effect of chemotherapy, it is less understood with hormone therapy. Researchers will ask 170 women to describe their hair loss symptoms ov…

This study is following 2000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain, nausea, or fatigue. No tre…

This study is looking at a protein called TRPC6 in the blood to see if it can predict which breast cancer patients will develop heart problems from chemotherapy. Researchers will collect blood samples from 200 patients to study genetic changes linked to heart damage. The goal is …

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study tests a support program for breast cancer survivors in Western New York. It combines group sessions and one-on-one mentoring with a long-term survivor to help women adjust to life after treatment. The goal is to see if this program helps connect survivors to resources …

This study examines DNA from 354 breast cancer patients who received bevacizumab to find genetic changes linked to high blood pressure caused by the drug. Researchers compare patients who developed severe hypertension with those who did not. The goal is to identify gene variants …

This study collects mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to create a large research bank that scientists can use in the future to improve early detection of breast cancer and other women's heal…

This study tests whether a computer-generated character (called PERLA) can help cancer patients learn about genetic testing as well as a human counselor does. The goal is to make genetic testing easier to access for people who often miss out, like those in rural areas or who spea…

This study collects tumor samples and medical information from 2000 adults with breast cancer that has spread or come back. The goal is to create a resource that helps researchers learn how the disease changes and responds to treatments. Participants provide samples and data but …

This study explores whether a computer algorithm called ENLIGHT can recommend approved drugs that might work better for people with advanced breast cancer that has stopped responding to standard treatments. About 175 adults with triple-negative or hormone-resistant breast cancer …

This study from Mayo Clinic talks to 20 breast cancer patients about their experience with skin irritation (radiation dermatitis) during or after radiotherapy. Researchers want to learn how it affects patients physically, emotionally, and socially. The goal is to better understan…

This study gathers information on short- and long-term side effects from proton therapy in adults with various cancers. Researchers will collect data from up to 5,000 participants to better understand and predict these side effects. The goal is to improve future treatment plannin…

This study tests a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect with support services, and overcome barriers like transportation or financial concerns. Researchers will measure how many …

This study tests an online platform for people with lung, colorectal, breast, or prostate cancer to track medication side effects and concerns at home. About 80 participants will use the tool and report on its ease of use and how it affects their health. The goal is to see if sel…

This study tests a new way to choose the next treatment for people with a common type of advanced breast cancer (ER-positive, HER2-negative). Doctors will use a special PET scan and blood tests to decide whether hormone therapy or chemotherapy is the better option. The goal is to…

This study tracks whether women at moderately increased risk for breast cancer get recommended screening MRIs within a year of genetic counseling. Researchers will also identify what makes it easier or harder for them to follow through. About 150 women aged 30 to 75 with certain …

This study follows 100 women with early-stage, hormone receptor-positive breast cancer to understand how their sleep changes during treatment. Researchers will use sleep watches and questionnaires to measure sleep quality and duration, and explore how stress, social support, and …

This study analyzes DNA from 575 breast cancer patients who received the chemotherapy drug paclitaxel. Researchers want to find genetic differences that make some people more likely to develop nerve damage (peripheral neuropathy) from treatment. By comparing DNA from those who ha…

This study aims to find out how many breast cancer patients stop coming to follow-up appointments within five years and why. Researchers will contact patients who have been lost to follow-up to update their health records and learn about barriers to care. The study involves 1,500…

This study looks at how the immune system reacts to breast and ovarian cancer. Researchers will collect tumor and blood samples from 160 women before surgery to study immune cells and find clues that might predict survival. No new treatment is given—the goal is to learn more abou…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor and fight cancer. About 36 adults with invasive breast cancer will have tumor samples taken before and after radiati…

This study looks at whether measuring body fat before and after breast reconstruction surgery can help predict outcomes. About 40 women having a mastectomy followed by immediate reconstruction will take part. The goal is to see if these measurements are easy to collect and if the…

This study is developing and testing a decision aid tool for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well the tool works in a group of 180 women who use it versus t…

This study looks at whether eating white button mushrooms can reduce chronic inflammation and improve immune cell function in obese postmenopausal women who have a high risk of breast cancer. Researchers will measure changes in immune cells and inflammatory markers in the blood. …

This study compares two ways to find the first lymph node under the arm in breast cancer patients: using ultrasound to mark the spot versus the usual method based on the hairline. The goal is to see if ultrasound allows a smaller cut, less tissue damage, and faster surgery. About…

This study tests a community program to increase cancer screening rates among low-income women in Ohio. The program includes patient education, media campaigns, and training health workers. Researchers will compare screening rates before and after the program to see if it helps m…

This study is testing new blood tests that look for signs of many different cancers at the same time. Researchers want to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will be split into three groups:…