BREAST CARCINOMA

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 adults with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone the…

This study tests a combination of three drugs (nivolumab, bicalutamide, and ipilimumab) to see if they can control metastatic HER2-negative breast cancer without needing chemotherapy. The approach aims to boost the immune system and block certain hormone signals. About 30 adults …

This study tests whether giving hormone therapy for 6 months before surgery can help remove all cancer in one piece, reducing the need for a full mastectomy. It includes 8 postmenopausal women with early-stage, low-risk, ER-positive breast cancer. The main goal is to see if the t…

This study tests whether giving a short course of radiation to the tumor area before surgery is safe and practical for women with early-stage breast cancer. About 98 women over age 50 with small, low-grade tumors will receive radiation, then have surgery. Researchers will check w…

This early-phase study tests a drug called veliparib combined with two standard chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors who also have liver or kidney dysfunction. The main goals are to find the safest dose and understand how the body p…

This study compares a single dose of radiation to five doses after breast cancer surgery for people with very early-stage breast cancer. The goal is to see if one dose works just as well at preventing the cancer from coming back, while also reducing side effects and improving qua…

This study compares two different chemotherapy combinations given before surgery for a fast-growing, hard-to-treat type of breast cancer called triple-negative inflammatory breast cancer. Researchers want to see if adding a targeted drug called panitumumab to standard chemotherap…

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This early-stage study tests a new radioactive tracer called 18F-αvβ6-BP to see if it can safely and effectively image several types of cancer, including breast, colorectal, lung, and pancreatic cancers. About 27 adults with primary or metastatic cancer will receive the tracer an…

This study tests a new radioactive tracer called [18F]FluorThanatrace (FTT) used with PET/CT scans to improve imaging of breast cancer. About 36 adults with known breast cancer will receive the tracer before standard surgery or biopsy. The goal is to see if FTT can help detect an…

This study looks at whether a special type of mammogram called contrast-enhanced mammography (CEM) can more accurately predict breast cancer in women with suspicious calcium spots in the breast. About 59 women with large areas of these spots will get both a standard and a contras…

This study tests a special mammogram that uses a dye injected into the arm to make breast tissue and blood vessels show up more clearly. The goal is to see if this method can find breast cancer better than standard mammograms in women with suspicious breast changes. About 100 wom…

This study tests a surgical procedure called vascularized lymph node transfer to lower the risk of lymphedema (arm swelling) in breast cancer patients having breast reconstruction. About 30 women who have already had mastectomy, lymph node removal, and radiation will receive this…

This study tests a lifestyle program of diet and exercise to reduce breast cancer risk in normal-weight postmenopausal women who have excess body fat. Researchers want to see if lowering body fat and inflammation can help prevent breast cancer. The study involves 40 women aged 50…

This study tests different programs to help people at high risk for cancer eat healthier and exercise more. The goal is to see which approach works best to increase physical activity and improve diet. About 337 people with a high BMI, low activity, or poor diet are taking part. T…

This study looks at whether adding a simple picture guide to standard counseling can help lower anxiety and depression in women with early-stage breast cancer who are about to start radiation therapy. About 62 women will take part, and their stress levels will be tracked using qu…

This study tests a mobile lifestyle program for women with breast cancer who have unhealthy habits. The program offers coaching on diet, exercise, stress management, mindfulness, and sleep. Researchers want to see if it's practical and helps improve quality of life. About 30 wome…

This study looks at two ways to give radiation to people with cancer that has spread to the brain. All participants are also receiving immunotherapy. The standard approach gives a single high dose of radiation, while the experimental approach gives a lower dose over a few days. T…

This study tests whether a genetic counseling program delivered through a hospital's online patient portal works as well as traditional in-person counseling for women at elevated risk for breast cancer. About 874 women will take part, and researchers will compare how well each gr…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study tests a computer app designed to help breast cancer patients decide about breast reconstruction surgery after mastectomy. The app shows personalized images of possible surgical outcomes based on each patient's treatment options and preferences. Researchers want to see …

This study was designed to see whether getting an IV in the arm that had lymph nodes removed for breast cancer treatment could increase the risk of lymphedema (arm swelling). Researchers planned to use a special dye and camera to watch how fluid moves through the arm's lymph syst…

This study collects tissue and blood samples from 2,400 people with early-onset breast, colon, kidney, liver, multiple myeloma, or prostate cancer. Researchers will analyze the samples to find genetic changes that may cause cancer at a young age, especially in racially and ethnic…

This study is testing a tool called MammoScreen that helps women and their doctors decide on breast cancer screening. About 1,100 women aged 40 to 74 will fill out a risk questionnaire through their online health portal. The goal is to see if the tool increases screening and iden…

This study follows 140 breast cancer patients who were part of the original BEAUTY study. Researchers will collect blood and tissue samples over time to learn why some breast cancers respond well to standard chemotherapy and others do not. The goal is to find clues that could lea…

This study examines skin and soft tissue removed during breast implant reconstruction after mastectomy. Researchers want to see if the physical properties of the skin can help predict complications like implant loss. The study involves 140 women who have had a mastectomy and a ti…

This study aimed to understand why women might want to receive their screening mammogram results immediately during the same visit. Researchers planned to survey female patients aged 30 and older scheduled for a mammogram at MD Anderson centers. The study was withdrawn before enr…