BREAST CARCINOMA

This study is testing whether giving hormone therapy pills for 6 months before breast cancer surgery helps surgeons remove all the cancer in one operation. It involves postmenopausal women with early-stage, hormone-sensitive breast cancer who haven't spread to lymph nodes. The go…

This study is testing if adding a targeted drug called panitumumab to standard chemotherapy works better than chemotherapy alone before surgery for a fast-growing, hard-to-treat type of breast cancer. It aims to see which combination shrinks the tumor more effectively, potentiall…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This study is testing whether just three radiation sessions can effectively treat early-stage breast cancer, instead of the usual weeks of treatment. It's designed for women over 50 with low-risk cancer who've had breast-conserving surgery. The goal is to see if this faster appro…

This study is testing whether a combination of tools can help cancer survivors living in rural areas better manage their health after treatment ends. Participants create their own survivorship care plan and some receive a phone-based education session. The goal is to see if this …

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This study is testing whether giving targeted radiation to part of the breast before surgery is a safe and feasible approach for early-stage breast cancer. It will enroll about 98 patients to see if this timing leads to fewer wound problems and better cosmetic outcomes compared t…

This early safety study aims to find the right dose and understand the side effects of a new drug combination for people with advanced solid tumors who also have liver or kidney problems. It tests adding a pill called veliparib to standard chemotherapy drugs. The main goal is to …

This early-phase study is testing a new radioactive tracer called 18F-αvβ6-BP to see if it can help doctors better locate cancer in the body. The tracer is given by IV, and then patients undergo several PET scans to see where it collects. The main goals are to check the safety of…

This study is testing whether a new radioactive imaging agent, called [18F]FluorThanatrace, can improve PET/CT scans for breast cancer. The goal is to see if this tracer can better detect an enzyme linked to cancer growth. The trial involves 36 adults with breast cancer who are s…

This study is testing if a special type of mammogram, called contrast-enhanced mammography (CEM), can better predict whether suspicious white spots (calcifications) seen on a regular mammogram are actually high-risk breast cancer. It involves 59 women who already need a biopsy fo…

This study is testing different ways to help people at high risk for cancer or cancer survivors become more active and eat healthier foods. Researchers are comparing methods like weekly phone calls, emails, daily text messages, and online forums to see which combinations work bes…

This study is testing a digital questionnaire called MammoScreen that helps identify women at average or increased risk for breast cancer. It aims to see if integrating this tool into electronic health records helps more women get appropriate screening and genetic counseling refe…

This study is testing whether a special surgical procedure can prevent a painful complication called lymphedema (arm swelling) in breast cancer patients having breast reconstruction. During reconstruction surgery, doctors transfer healthy lymph nodes from another part of the body…

This study is testing whether a 4-month diet and exercise program can help lower the risk of breast cancer. It focuses on postmenopausal women who are a normal weight but have high body fat, which can increase cancer risk. Researchers want to see if this lifestyle program is prac…

This study is testing a mobile health program designed to help women with breast cancer improve their lifestyle habits. The program provides coaching on healthy eating, exercise, stress management, and sleep over several weeks. Researchers want to see if this approach is practica…

This study follows up with 140 patients from a previous breast cancer trial (BEAUTY) to learn more about how cancer responds to treatment over time. Researchers will collect blood samples and health information to understand why some cancers come back and others don't. The goal i…

This study aimed to see if placing an IV line and giving fluids in the arm of breast cancer survivors at risk for lymphedema (chronic arm swelling) is safe and does not damage the lymphatic system. Researchers planned to use a special fluorescent dye and imaging to track fluid fl…

This study aimed to understand why some women might want to receive their screening mammogram results immediately during their appointment, instead of waiting days for a report. Researchers planned to survey women aged 30 and older who were scheduled for a mammogram at specific c…

This study aimed to understand how community cancer clinics test for biomarkers—specific genetic changes in tumors—to help guide treatment decisions for common cancers like breast, lung, and colorectal. It planned to survey pathology labs to see what tests they run, how quickly t…

This study is testing whether a new, more convenient online genetic counseling approach works as well as traditional in-person counseling for women at higher risk for breast cancer. Researchers are comparing two methods: one uses educational videos and online tools through a pati…

This study aims to understand why certain cancers develop at younger ages in people from different racial and ethnic backgrounds. Researchers will collect tumor tissue and blood samples from 2,400 patients during their regular cancer surgeries. By analyzing these samples, they ho…

This study is testing a web-based education tool called HOPE-Genomics to see if it helps cancer patients better understand their personal genetic test results and general cancer genomics. Researchers are comparing the tool's effectiveness against standard education methods in abo…

This study is testing a new computer app designed to help breast cancer patients make more informed decisions about breast reconstruction surgery. The app shows patients personalized images of what different reconstruction options might look like for their own body. Researchers w…

This study aims to understand how the physical properties of skin after mastectomy might predict risks during breast reconstruction surgery. Researchers will collect and analyze tissue samples from 140 women undergoing standard implant exchange procedures. The goal is to gather k…