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Computer algorithm could unlock hidden treatments for aggressive breast cancer

NCT ID NCT07067138

Terminated Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a computer algorithm called ENLIGHT can help find better drug matches for people with advanced breast cancer that has stopped responding to standard treatments. About 175 adults with triple-negative or hormone-resistant breast cancer will have their tumor tissue analyzed by the algorithm. If the algorithm suggests a drug that is already approved for another use, participants may receive that drug at the NIH. The goal is to see if this approach is feasible and can lead to tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ENLIGHT algorithm (computational tool)
What this could lead to
If successful, this could show that a computer algorithm can help doctors choose more effective, already-approved drugs for hard-to-treat breast cancers.
What could go wrong
This is an early exploratory study, currently suspended, with no guarantee that the algorithm's recommendations will actually improve outcomes. The approach is untested in this setting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm hormone-resistant breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CARCINOMA CANCER OF THE BREAST MALIGNANT NEOPLASM OF BREAST

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

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