Experimental drug duo targets Hard-to-Treat HER2 cancers

NCT ID NCT06157892

Ongoing Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This study tests two drugs together—disitamab vedotin and tucatinib—in people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combination is safe and shrinks tumors. About 172 participants will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: disitamab vedotin and tucatinib
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced HER2-positive breast or stomach cancers that have stopped responding to standard therapies.
What could go wrong: This is an early-phase trial (phase 1b/2) with a small number of participants, so the combination may prove unsafe or ineffective. Side effects from both drugs could be significant.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal junction adenocarcinoma HER2 positive breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER ADVANCED GASTRIC CANCER BREAST NEOPLASMS GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA HER2 LOW BREAST NEOPLASMS HER2 POSITIVE BREAST NEOPLASMS METASTATIC BREAST CANCER METASTATIC GASTRIC CANCER STOMACH NEOPLASMS TRIPLE NEGATIVE BREAST NEOPLASMS

Contacts and locations

Locations

A.O.U. Federico II

Naples, Campania, 80131, Italy
A.O.U. Federico II- U.O.C. Diagnostica per lmmagini e Radioterapia

Naples, 80131, Italy
Atlanta Cancer Care - Atlanta

Atlanta, Georgia, 30342, United States
Atlanta Cancer Care - Cumming

Cumming, Georgia, 30041, United States
Azienda Ospedaliera Universitaria (AOU) Federico II

Naples, Campania, 80131, Italy
Azienda Ospedaliera Universitaria Integrata di Verona.

Verona, Veneto, 37134, Italy
BC Cancer Kelowna.

Kelowna, British Columbia, V1Y 5L3, Canada
Banner-University Medical Center Tucson Campus

Tucson, Arizona, 85704, United States
Banner-University Medical Center Tucson Campus

Tucson, Arizona, 85719, United States
Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Cancer Institute Hospital of JFCR

Koto-ku, Tokyo, 135-8550, Japan
Carbone Cancer Center / University of Wisconsin

Madison, Wisconsin, 53792, United States
Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital

Taoyuan, 333, Taiwan
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF)

Berlin, 12203, Germany
Chungbuk National University Hospital

Cheongju-si, 28644, South Korea
Colorado West Healthcare System, dba Community Hospital

Grand Junction, Colorado, 81505, United States
Colorado West Healthcare, dba Grand Valley Oncology

Grand Junction, Colorado, 81505, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dana Farber Cancer Institute- Chestnut Hill

Newton, Massachusetts, 02459, United States
Dong-A University Hospital

Busan, Other, 49201, South Korea
Ecg Medica Sl

Valencia, 46004, Spain
Farmacia-Ensayos. Planta S - Hospital Universitario HM Sanchinarro-CIOCC-START Madrid

Madrid, 28050, Spain
Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University of Washington

Seattle, Washington, 98109, United States
Gachon University Gil Medical Center

Incheon, 21565, South Korea
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Georgia Cancer Specialists - Annex

Atlanta, Georgia, 30341, United States
Georgia Cancer Specialists - Athens

Athens, Georgia, 30606, United States
Georgia Cancer Specialists - Blairsville

Blairsville, Georgia, 30512, United States
Georgia Cancer Specialists - Canton

Canton, Georgia, 30115, United States
Georgia Cancer Specialists - Cumming

Cumming, Georgia, 30041, United States
Georgia Cancer Specialists - Decatur

Decatur, Georgia, 30033, United States
Georgia Cancer Specialists - Macon

Macon, Georgia, 31217, United States
Georgia Cancer Specialists - Marietta

Marietta, Georgia, 30060, United States
Georgia Cancer Specialists-Northside

Atlanta, Georgia, 30342, United States
Grupo Hospitalario QuironSalud

Erandio Bizkaia, 48950, Spain
H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, 33612, United States
Harborview Medical Center

Seattle, Washington, 98104, United States
Heidelberg University Hospital and German Cancer Research Center

Heidelberg, 69120, Germany
Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain
Hospital Universitari Vall d´Hebron

Barcelona, 08035, Spain
Hospital Universitario de Basurto

Bilbao, 48013, Spain
Humanitas Istituto Clinico Catanese

Misterbianco (CT), Sicily, 95045, Italy
Institut Catala d'Oncologia

Barcelona, 08908, Spain
Investigational Drug Service

Long Island City, New York, 11101, United States
Istituto Europeo di Oncologia

Milan, Lombardy, 20141, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale.

Naples, Campania, 80131, Italy
Japanese Foundation for Cancer Research

Koto-ku, Tokyo, 135-8550, Japan
Korea University Anam Hospital

Seoul, 02841, South Korea
Linkou Chang Gung Memorial Hospital

Taoyuan City, 333, Taiwan
MSK Basking Ridge

Basking Ridge, New Jersey, 07920, United States
MSK Bergen.

Montvale, New Jersey, 07645, United States
MSK Commack.

Commack, New York, 11725, United States
MSK Monmouth.

Middletown, New Jersey, 07748, United States
MSK Nassau.

Uniondale, New York, 11553, United States
MSK Westchester.

Harrison, New York, 10604, United States
Massachusetts General Hospital.

Boston, Massachusetts, 02114, United States
MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Memorial Hospital

Shiloh, Illinois, 62269, United States
Memorial Sloan Kettering - Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering - Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering - Westchester

Harrison, New York, 10604, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center - Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center - Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Cancer Center - Main Hospital

New York, New York, 10065, United States
Memorial Sloan Kettering- Nassau

Uniondale, New York, 11553, United States
Moffitt Cancer Center - International Plaza

Tampa, Florida, 33607, United States
Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States
Moffitt Cancer Center at Wesley Chapel

Wesley Chapel, Florida, 33544, United States
Moffitt McKinley Hospital

Tampa, Florida, 33612, United States
National Cancer Center

Goyang-si, Other, 10408, South Korea
National Cheng Kung University Hospital

Tainan, 704017, Taiwan
National Cheng Kung University Hospital

Tainan, 704, Taiwan
National Taiwan University Cancer Center

Taipei, 106, Taiwan
National Taiwan University Hospital

Taipei, 100225, Taiwan
National Taiwan University Hospital

Taipei, 100, Taiwan
Niguarda Ca' Granda Hospital

Milan, Lombardy, 20162, Italy
Northside Hospital

Atlanta, Georgia, 30342, United States
Northside Hospital, Inc.- Central Research Department

Atlanta, Georgia, 30342, United States
Okayama University Hospital

Okayama, 700-8558, Japan
Ottawa Hospital Cancer Centre

Ottawa, Ontario, K1H 8L6, Canada
Peninsula & South Eastern Hematology and Oncology Group (PASO)

Frankston, Victoria, 3199, Australia
Peninsula & South Eastern Hematology and Oncology Group (PASO)

Frankston, Australia
Peter MacCallum Cancer Centre

Melbourne, 3000, Australia
Providence Health and Services Washington and Montana

Renton, Washington, 98057, United States
Quirén Salud Barcelona

Barcelona, 08023, Spain
Renown Regional Medical Center

Reno, Nevada, 89502, United States
SCRI Oncology Partners

Nashville, Tennessee, 37203, United States
START Madrid-CIOCC_Hospital HM Sanchinarro

Madrid, 28050, Spain
Saint Francis Hospital / Bon Secours - South Carolina

Greenville, South Carolina, 29607, United States
Saint Luke's Cancer Institute LLC

Kansas City, Missouri, 64111, United States
Saint Luke's Hospital Investigational Pharmacy

Kansas City, Missouri, 64111, United States
San Juan Oncology Associates

Farmington, New Mexico, 87401, United States
Sarah Cannon Research Institute - Pharmacy

Nashville, Tennessee, 37203, United States
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Showa Medical University Hospital

Tokyo, 142-8666, Japan
Showa University Hospital

Shinagawa-ku, Tokyo-to, 142-8666, Japan
Siteman Cancer Center - North County

Florissant, Missouri, 63031, United States
Siteman Cancer Center - Shiloh

Shiloh, Illinois, 62269, United States
Siteman Cancer Center - South County

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St Peters

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - West County

Creve Coeur, Missouri, 63141, United States
Slade Health

Mount Waverley, Victoria, 3149, Australia
Slade Pharmacy Frankston

Frankston, Victoria, 3199, Australia
St Bartholomew's Hospital

London, EC1M 6BQ, United Kingdom
St. Vincent's Hospital, The Catholic University of Korea

Suwon, 16247, South Korea
Suburban Hematology-Oncology Associates - Duluth

Duluth, Georgia, 30096, United States
Suburban Hematology-Oncology Associates- Lawrenceville

Lawrenceville, Georgia, 30046, United States
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Tennessee Oncology-Nashville/Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
The Christie NHS Foundation Trust

Manchester, M20 4GJ, United Kingdom
The Royal Marsden Hospital

Sutton, Surrey, SM2 5PT, United Kingdom
The Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
The Royal Marsden NHS Foundation Trust

Sutton, Surrey, SM2 5PT, United Kingdom
The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom
The Royal Marsden NHS Foundation Trust

Sutton, SM2 5PT, United Kingdom
The Royal Marsden NHS Foundation Trust (RM)

London, SW3 6JJ, United Kingdom
The University of Arizona Cancer Center-Main

Tucson, Arizona, 85724, United States
The University of Arizona Cancer Center-North Campus Pharmacy, Attn: Kelly Myrdal

Tucson, Arizona, 85719, United States
UC Irvine Health - Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UC Irvine Medical Center

Orange, California, 92868, United States
UCLA Department of Medicine - Hematology & Oncology

Santa Monica, California, 90404, United States
UCLA Hematology/Oncology - Parkside

Santa Monica, California, 90404, United States
Universitatsklinikum Essen

Essen, 45147, Germany
University Health Network - Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
University of Arizona Cancer Center - North Campus

Tucson, Arizona, 85719, United States
University of California, San Francisco | HDFCCC - Hematopoietic Malignancies

San Francisco, California, 94158, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Washington University School of Medicine - Siteman Cancer Center

St Louis, Missouri, 63110, United States
Zangmeister Cancer Center

Columbus, Ohio, 43219, United States

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