STOMACH NEOPLASMS

This phase II trial is testing a combination of three drugs—trastuzumab deruxtecan, capecitabine, and rilvegostomig—in people with HER2-positive, locally advanced stomach cancer that cannot be removed by surgery right away. The goal is to see if giving these drugs before and afte…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study tests a new drug called IAH0968, given alone or with chemotherapy (CAPEOX), in people with advanced HER2-positive stomach cancer or other solid tumors. The goal is to see if the combination is safe and helps slow cancer growth better than standard treatment. About 574 …

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study is testing a new way to give radiation therapy (called PULSAR) along with standard chemotherapy and immunotherapy for people with advanced stomach cancer that cannot be removed with surgery. The radiation is given in high doses every few weeks, tailored to each patient…

This early-stage trial is testing a new drug called sigvotatug vedotin, alone or with other cancer medicines, in people with advanced solid tumors like lung, head and neck, and breast cancers. The study aims to find a safe dose and check for side effects. About 1,000 participants…

This study tests two drugs together—disitamab vedotin and tucatinib—in people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combination is safe and shrinks tumors. About 172 participants will take part.

This phase II trial tests whether adding surgery and radiation to standard chemotherapy can improve outcomes for people with stomach cancer that has spread only to nearby lymph nodes. About 54 participants will receive either standard chemo or a more intensive plan including chem…

This phase 2 trial tests whether adding the immunotherapy drug serplulimab to standard chemotherapy before surgery helps patients with advanced stomach or gastroesophageal junction cancer. About 116 participants will receive either the combo or chemo alone for three cycles before…

This early-phase study tests an experimental drug called PF-08046050 in adults with advanced solid tumors (like lung, colon, or stomach cancer) that have come back or not improved with standard treatments. The drug is designed to stick to cancer cells and kill them. The main goal…

This study compares two endoscopic procedures—argon plasma coagulation (APC) and endoscopic mucosal resection (EMR)—for treating small (1 cm or smaller) precancerous growths in the stomach called gastric adenomas with low-grade dysplasia. About 160 adults will be randomly assigne…

This phase 2 trial tests whether adding two drugs (adebrelimab and famitinib) to standard chemotherapy (irinotecan) can help people with advanced stomach or gastroesophageal junction cancer whose first treatment stopped working. About 66 participants will be randomly assigned to …

This study compares two types of surgery for advanced stomach cancer: keyhole (laparoscopic) and open total gastrectomy. About 1,018 patients will be randomly assigned to one of the two procedures. The main goal is to see if keyhole surgery offers similar long-term survival with …

This study looks at whether a small tissue sample taken during an endoscopy (biopsy) can give the same information about gastric cancer as a larger sample taken during surgery. Researchers will compare results from 510 patients to see if the biopsy is just as accurate for key can…

This study tests if a new single-port robotic surgery system is as safe and effective as traditional laparoscopic surgery for people with early-stage stomach cancer. About 90 adults will be randomly assigned to one of the two surgical methods. The main goal is to see if the new s…

This study aims to collect blood, urine, tumor samples, and health data from up to 1,000 people with malignant mesothelioma or other cancers that express a protein called mesothelin. Participants will be followed over time to track the course of their disease. The goal is to buil…

This study translates and validates a Korean quality-of-life questionnaire (KOQUSS-40) for Spanish-speaking patients who had stomach cancer surgery. Researchers will enroll 505 adults who are at least one month past surgery and cancer-free. The goal is to create a reliable tool t…

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tumor samples, healthy tissue, and blood to build a biobank. The goal is to understand why stomach cancer is more common in the We…

This study compares two surgical procedures for patients with a specific type of cancer where the stomach meets the esophagus. Half of the 120 participants will have only the upper part of the stomach removed (proximal gastrectomy), while the other half will have the entire stoma…