New radiation drug targets Hard-to-Treat cancers

NCT ID NCT07114601

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the drug is safe, tolerable, and effective at shrinking tumors. Participants will receive the drug alone or with standard care, and the study lasts up to 36 weeks.

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Conditions

The condition(s) this trial relates to.

borderline ovarian serous tumor breast neoplasm castration-resistant prostate carcinoma colorectal carcinoma colorectal neoplasm endometrial carcinoma endometrium neoplasm esophageal adenocarcinoma Esophageal Neoplasms esophageal squamous cell carcinoma estrogen-receptor positive breast cancer gastric adenocarcinoma gastric neoplasm gastroesophageal junction adenocarcinoma hormone receptor-positive breast cancer metastatic neoplasm metastatic prostate carcinoma Neoplasm Metastasis neoplasm of esophagus ovarian serous adenocarcinoma prostate cancer prostate neoplasm triple-positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST NEOPLASMS COLORECTAL NEOPLASMS ENDOMETRIAL NEOPLASMS ESOPHAGEAL NEOPLASMS NEOPLASM METASTASIS PROSTATE NEOPLASM STOMACH NEOPLASMS

Contacts and locations

Locations

BAMF Health Inc.
RECRUITING

Grand Rapids, Michigan, 49503, United States
Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Biogenix Molecular, LLC
RECRUITING

Miami, Florida, 33165, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Emory University School of Medicine - Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Hospital Universitari Quiron Dexeus Barcelona
NOT_YET_RECRUITING

Barcelona, 08028, Spain
Institut Curie
NOT_YET_RECRUITING

Paris, 75005, France
Institut de Cancerologie de l'Ouest - site St-Herblain
NOT_YET_RECRUITING

Saint-Herblain, 44805, France
Juravinski Cancer Centre
RECRUITING

Hamilton, L8V 5C2, Canada
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)
NOT_YET_RECRUITING

München, 81675, Germany
Kyoto University Hospital
NOT_YET_RECRUITING

Kyoto, 606-8507, Japan
LMU Klinikum Muenchen-Campus Grosshadern
NOT_YET_RECRUITING

München, 80336, Germany
Lady Davis Institute for Medical Research Jewish General Hospital
NOT_YET_RECRUITING

Montreal, H3T 1E2, Canada
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Moffitt
RECRUITING

Tampa, Florida, 33612, United States
National Cancer Center Hospital East
NOT_YET_RECRUITING

Chiba, 277-8577, Japan
New York University (NYU) Langone Medical Center
NOT_YET_RECRUITING

New York, New York, 10016, United States
Peking Union Medical College Hospital of Chinese Academy of Medical Sciences
NOT_YET_RECRUITING

Beijing, 100730, China
Princess Margaret Hospital
RECRUITING

Toronto, M5G 2M9, Canada
South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz
NOT_YET_RECRUITING

Madrid, 28040, Spain
Stanford University Medical Center
RECRUITING

Stanford, California, 94305, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, M4N 3M5, Canada
Texas Oncology - DFW (Sammons CC)
NOT_YET_RECRUITING

Dallas, Texas, 75246, United States
Tianjin Cancer Hospital Airport Hospital
NOT_YET_RECRUITING

Tianjin, 300060, China
Universitaetsklinikum Erlangen
NOT_YET_RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Essen
NOT_YET_RECRUITING

Essen, 45147, Germany
University of California, Los Angeles (UCLA)
RECRUITING

Santa Monica, California, 90404, United States
University of Pittsburgh Medical Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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