Immunotherapy boosts chemo before stomach cancer surgery in new trial

NCT ID NCT06576921

Recruiting now Disease control Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding the immunotherapy drug serplulimab to standard chemotherapy before surgery helps patients with advanced stomach or gastroesophageal junction cancer. About 116 participants will receive either the combo or chemo alone for three cycles before and after surgery. The main goal is to see if the combo increases the rate of complete tumor disappearance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: serplulimab (an immunotherapy drug) combined with chemotherapy (nab-paclitaxel, S-1, oxaliplatin)
What this could lead to: If it works, this could lead to a more effective pre-surgery treatment for advanced stomach cancer, helping more patients achieve complete tumor removal.
What could go wrong: This is an early phase 2 trial with only 116 participants, so results may not apply to everyone. Adding immunotherapy to chemo can increase side effects like immune-related inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ADENOCARCINOMA OF ESOPHAGOGASTRIC JUNCTION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

gastric cancer gastric neoplasm gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNE CHECKPOINT INHIBITORS STOMACH NEOPLASMS

Contacts and locations

Locations

Department of Digestive surgery, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi' an, China
RECRUITING

Xi'an, Shaanxi, 710032, China
Department of General Surgery, Tangdu Hospital, Air Force Medical University
RECRUITING

Xi'an, Shaanxi, 710032, China
Department of General Surgery, The 986th Military Hospital, Air Force Medical University
RECRUITING

Xi'an, Shaanxi, 710032, China
The fourth hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Heibei Province, 050000, China
Tianjin Medical University Cancer Institute & Hospital
RECRUITING

Tianjin, 300060, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.