Can an immune booster after lung cancer surgery keep the disease at bay?

NCT ID NCT07748325

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial asks whether giving sintilimab, an immune checkpoint inhibitor, after complete surgical removal of non-small cell lung cancer can improve outcomes for patients at high risk of recurrence. Participants who already received chemotherapy plus an immune checkpoint inhibitor before surgery are randomly assigned to either receive sintilimab for up to a year or to be observed without additional treatment. The main goal is to see if sintilimab improves the proportion of patients who remain cancer-free at 18 months after surgery, with secondary focus on overall survival and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Sintilimab, an immune checkpoint inhibitor, given intravenously every 4 weeks for up to 1 year after surgery.
What this could lead to
If effective, this could reduce the chance of lung cancer returning after surgery, potentially improving long-term survival for high-risk patients.
What could go wrong
This is a phase II trial with a modest size, so results may not be definitive. Sintilimab can cause immune-related side effects, and not all patients may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Suining Central Hospital

    RECRUITING

    Suining, Sichuan, China

  • West China Hospital, Sichuan University

    RECRUITING

    Chengdu, Sichuan, 610041, China

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