STOMACH NEOPLASMS

This study compares two procedures for removing small precancerous growths (≤1 cm) in the stomach: argon plasma coagulation (APC), a simpler, less invasive method, and endoscopic mucosal resection (EMR), which removes tissue for testing. About 160 adults with low-grade dysplasia …

This study tests whether adding the drug serplulimab to standard chemotherapy before surgery can better shrink advanced stomach or gastroesophageal junction cancer. About 116 adults will receive either the combination or chemo alone for three cycles before and after surgery. The …

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment involves collecting a patient's own immune cells, modifying them in a lab to better re…

This study tests a new drug called LY4337713, which delivers radiation directly to cancer cells that have a specific protein (FAP). It is for adults with advanced or spread-out cancers like pancreatic, breast, ovarian, colorectal, esophageal, stomach, or bile duct cancer. The mai…

This study compares two surgical methods for removing the entire stomach in people with locally advanced gastric cancer. About 1,018 adults aged 18-75 with tumors in the middle or upper stomach will be randomly assigned to either laparoscopic (keyhole) or open surgery. The main g…

This study tests whether adding surgery and radiation to standard chemotherapy can improve outcomes for people with stomach cancer that has spread to specific lymph nodes in the back of the abdomen. About 54 participants will receive either standard treatment or a combination of …

This study compares two surgical procedures—removing part or all of the stomach—for people with advanced cancer where the esophagus meets the stomach. About 120 participants will be randomly assigned to one surgery or the other. The goal is to see which approach leads to longer c…

This study tests a combination of two drugs—disitamab vedotin and tucatinib—for people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combo is safe and can shrink or control tumors. About 172 adults with these cancers who have a…

This study tests whether combining targeted therapies (Trastuzumab Deruxtecan and Capecitabine, with or without Rilvegostomig) before and after surgery can help people with a certain type of advanced stomach cancer (HER2-positive) that cannot be removed right away. About 50 adult…

This study tests whether a combination of three drugs (adebrelimab, famitinib, and irinotecan) works better than irinotecan alone for people with advanced stomach cancer whose first treatment has stopped working. About 66 participants will be randomly assigned to one of the two g…

This early-stage trial tests a drug called sigvotatug vedotin, alone or with other medicines, in people with advanced solid tumors like lung, head and neck, or breast cancer. The main goal is to check safety and find the right dose. About 1,000 participants will join this study t…

This study tests an experimental drug called PF-08046050 in people with advanced solid tumors (cancers that have spread or can't be removed). The drug is designed to stick to cancer cells and kill them. The main goal is to check safety and find the right dose. About 914 adults wi…

This study checks if a small tissue sample taken during an endoscopy (a tube down the throat) can accurately diagnose the type, grade, and key features of stomach cancer, compared to the larger sample removed during surgery. About 510 adults with stomach cancer will participate. …

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tissue and blood samples to build a biobank for future studies on other risk factors, like environmental pollutants. The goal is t…

This study aims to translate and validate a Korean quality-of-life questionnaire into Spanish for people who have had stomach cancer surgery. Researchers will enroll 505 adults who are at least one month past surgery and have no cancer recurrence. The goal is to create a reliable…

This study collects blood, urine, and tumor samples from up to 1,000 people with malignant mesothelioma and other cancers that express mesothelin. The goal is to build a tissue bank for future research into these diseases. Participants are followed over time to track their health…