New drug targets Hard-to-Treat cancers in early trial

NCT ID NCT06131840

Recruiting now Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This early-phase study tests an experimental drug called PF-08046050 in adults with advanced solid tumors (like lung, colon, or stomach cancer) that have come back or not improved with standard treatments. The drug is designed to stick to cancer cells and kill them. The main goal is to check safety and find the right dose.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm gastric carcinoma gastric neoplasm gastroesophageal junction adenocarcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG COLORECTAL NEOPLASMS GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA PANCREATIC DUCTAL ADENOCARCINOMA SMALL CELL LUNG CARCINOMA STOMACH NEOPLASMS

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ApoEx NKS
RECRUITING

Stockholm, 17176, Sweden
Ascires CETIR
RECRUITING

Esplugues de Llobregat, 08950, Spain
Ascires Cetir
RECRUITING

Barcelona, 08029, Spain
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
RECRUITING

Duarte, California, 91010, United States
Diagnostic Centre
RECRUITING

London, W1G 7AF, United Kingdom
Edinburgh Cancer Centre, Western General Hospital
RECRUITING

Edinburgh, Scotland, EH4 2XU, United Kingdom
Florida Cancer Specialists
RECRUITING

Orlando, Florida, 32827, United States
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, 201321, China
Gustave Roussy
RECRUITING

Villejuif, 94800, France
Hadassah Medical Organization
NOT_YET_RECRUITING

Jerusalem, 91120, Israel
Hospital Universitario HM Sanchinarro-CIOCC-START Madrid
RECRUITING

Madrid, 28050, Spain
IP Address: City of Hope Investigational Drug Services(IDS)
RECRUITING

Duarte, California, 91010, United States
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
RECRUITING

L'Hospitalet de Llobregat, Catalunya [cataluña], 08908, Spain
Institut Gustave Roussy
RECRUITING

Villejuif, Paris, 94805, France
Karolinska University Hospital
RECRUITING

Solna, 171 64, Sweden
Lothian Health Board
RECRUITING

Edinburgh, EH3 9DN, United Kingdom
Mayo Clinic
RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Cancer Center
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
MidAmerica Cancer Care
NOT_YET_RECRUITING

Kansas City, Missouri, 64132, United States
NEXT Dallas
NOT_YET_RECRUITING

Irving, Texas, 75039, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Netherlands Cancer Institute
RECRUITING

Amsterdam, 1066CX, Netherlands
Radiology
RECRUITING

London, W1G 8PP, United Kingdom
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain Region
RECRUITING

Salt Lake City, Utah, 84119, United States
Sarah Cannon Research Institute - Pharmacy
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute UK
RECRUITING

London, W1G 6AD, United Kingdom
Sarah Cannon Research Institute at Florida Cancer Specialists
RECRUITING

Orlando, Florida, 32827, United States
Servicio de Farmacia ICO - Planta 0
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Shandong First Medical University Cancer Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
Sidney Kimmel Comprehensive Cancer at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21287, United States
South Texas Accelerated Research Therapeutics Mountain Region
RECRUITING

West Valley City, Utah, 84119, United States
South Texas Accelerated Research Therapeutics, LLC
RECRUITING

San Antonio, Texas, 78229, United States
The Harley Street Clinic
RECRUITING

London, W1G 7LJ, United Kingdom
The Harley Street Clinic (THSC)
RECRUITING

London, Other, W1G 8BJ, United Kingdom
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, 510655, China
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
University Health Network, Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)
RECRUITING

Aurora, Colorado, 80045, United States
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom

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