BREAST CARCINOMA

This study is testing whether a smart pillbox, combined with text message reminders, can help people with advanced breast cancer remember to take their oral medication correctly. The goal is to see if this technology helps patients stick to their complex treatment schedule better…

This study is testing a new drug called GTAEXS617 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like head & neck, lung, pancreatic, ovarian, and bre…

This study is testing whether a patient navigation program can help reduce disparities in breast cancer care. The program helps newly diagnosed women understand their treatment options, connect with support services, and overcome barriers to getting care. Researchers want to see …

This study is testing if changing the order of breast cancer treatments improves how women feel about their bodies after surgery. It compares giving radiation therapy before breast removal and reconstruction (the new approach) to the standard method of radiation after surgery. Th…

This trial aims to help doctors choose the most effective second treatment for people with advanced breast cancer that has stopped responding to initial hormone therapy. It uses special scans and blood tests to guide whether patients should receive more hormone-based treatments o…

This study is testing a much shorter radiation schedule for people with early-stage breast cancer. Instead of treatments over several weeks, participants receive radiation to the whole breast and the surgical area at the same time, completed in just 5 daily sessions. The main goa…

This study is testing whether giving a shorter, more intense course of radiation therapy *before* breast cancer surgery is as safe and effective as giving it *after* surgery. It aims to see if the pre-surgery timing can reduce side effects and treatment time for 120 patients with…

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if giving smaller radiation doses over several days causes fewer side effects than the standard single-day treatment. The trial…

This study is testing whether a computer algorithm called ENLIGHT can find better treatment options for people with aggressive, metastatic breast cancer that has stopped responding to standard therapies. Researchers will analyze a tumor sample from each participant using the algo…

This study is for people with metastatic breast cancer whose current medication is working well but who have a few new spots of cancer growth. Researchers want to see if using very precise, high-dose radiation on just those few spots can control them, allowing patients to safely …

This study aims to compare two types of imaging scans to see which is better at finding and tracking metastatic lobular breast cancer. Researchers will test a new scan (FES PET/CT) against the standard scan (FDG PET/CT) in 30 adults with this specific cancer type. The goal is to …

This study is testing if a special type of mammogram called CESM is better than standard scans at finding the cause of unusual nipple discharge. CESM uses a safe dye injected into the vein to make breast tissue clearer on the images. The goal is to see if this method can more acc…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This early study is testing a new 3D ultrasound imaging technology to see if it can better evaluate lymph nodes in people with breast cancer. Researchers want to know if this 3D method is more accurate than standard 2D ultrasound at telling if a lymph node is cancerous or benign.…

This Mayo Clinic study is testing a new type of breast ultrasound to see if it can better find breast cancer and check if treatment is working. It involves 550 adult patients who either have a suspicious breast lump needing a biopsy or have been diagnosed with breast cancer and a…

This study is testing whether combining a special contrast-enhanced ultrasound with artificial intelligence (AI) can better determine if suspicious breast masses are cancerous or benign. Researchers will scan 100 women who have been recommended for a biopsy to see if this approac…

This study is comparing two ways of creating mammogram images to see which helps doctors better spot breast cancer. Researchers will look at the medical records and past scans of 750 women to analyze the performance of a newer image type called 'synthetic mammography' against the…

This study is testing a new type of mammogram that uses a safe dye injected into the vein to make breast tissue clearer. The goal is to see if this enhanced scan can better identify which suspicious-looking areas are cancer and help doctors target the right spot for a biopsy. It …

This study is testing a new imaging method called photoacoustic tomography, which uses light and sound waves together. It aims to get clearer pictures of breast tissue, especially for people with dense breasts where mammograms can miss things. The goal is to see if this method ca…

This study is testing whether using an ultrasound machine to guide where surgeons make an incision during breast cancer surgery helps them find the first lymph node more easily. Researchers will compare this ultrasound-guided method to the standard technique in 40 patients. They …

This study is testing whether a new type of blood test, called a liquid biopsy, can accurately detect breast cancer. Researchers will compare the blood test results to standard methods like mammograms and biopsies in 490 women. The goal is to see if this easier test could one day…

This study is testing a personalized approach to using the drug tamoxifen to prevent breast cancer in premenopausal women at higher-than-average risk. Researchers want to see if starting with a low dose and increasing it only for women who don't show a good initial response on th…

This study is testing whether people who get screened for breast or lung cancer, or their supportive friends and family, can encourage others to get screened too. Researchers want to see if this 'sphere of influence' approach can increase screening rates, especially for lung canc…

This study is testing whether a comprehensive prevention program can help drain fluid from the arm and stop lymphedema (chronic arm swelling) from developing. It involves 285 women with breast cancer who are having surgery to remove lymph nodes under their arm. The main goal is t…

This study is testing two drugs, acolbifene and a low dose of tamoxifen, to see which is better at preventing breast cancer in premenopausal women who are at high risk. It will involve 80 women who will take one of the drugs daily for six months. Researchers will check for change…

This study is testing whether a low dose of the drug tamoxifen, taken with or without high-dose omega-3 fish oil supplements, can help prevent breast cancer in women at high risk. It is for overweight or obese postmenopausal women who have specific risk factors, like a family his…

This study is testing whether taking a daily low-dose aspirin can reduce inflammation in breast tissue, which might help prevent breast cancer in women who have recently had a baby. It involves 100 women under age 45 who have given birth within the last 10 years and need a breast…

This study is testing a community program designed to help more low-income and uninsured women get screened for breast, cervical, and colorectal cancer. The program works with clinics, healthcare providers, patients, and entire communities through education, reminders, and outrea…

This study is testing whether a patient navigation program can help women at high risk for breast cancer access and use recommended prevention strategies. The program provides information and monthly phone support to help participants understand their risk and options like geneti…

This study is testing a free support program designed to help breast cancer survivors in Western New York transition to life after their main cancer treatments are finished. The program combines group support sessions with one-on-one mentoring from a long-term survivor. Researche…

This study is testing whether a 12-week program of breathing exercises done at home can help reduce side effects for people undergoing chemotherapy for breast cancer. The exercises aim to strengthen breathing muscles and may help lessen heart and lung strain, fatigue, and stress …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing two different walking exercise programs for women receiving chemotherapy for breast cancer. It aims to see which approach is better at improving fitness and reducing cancer-related fatigue. The study will enroll 140 participants to compare a fixed weekly wal…

This study aims to understand if using cannabis or related products helps people manage symptoms like pain and nausea during cancer treatment. It will follow 2,000 adults newly diagnosed with certain cancers who are starting chemotherapy or immunotherapy. Researchers will track p…

This study is testing whether a virtual exercise and wellness program can help reduce fatigue and improve symptoms for breast cancer patients undergoing radiation treatment. Participants will use activity trackers and try online classes like yoga, tai chi, and cardio. The goal is…

This study is testing whether two cannabis-based treatments (CBD alone or a THC:CBD mix) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy. It will involve 120 breast and colon cancer survivors who have finished treatment but still suffer from these sid…

This study is testing a mobile app designed to support Black women after breast cancer treatment. The app provides culturally tailored educational materials and resources to help survivors manage their health and access follow-up care. Researchers want to see if using this digita…

This small, early study is testing whether a wearable headband that guides meditation can help breast cancer survivors manage anxiety and insomnia. Forty participants who report these symptoms will use the headband at night and for short daily meditations over 8 weeks. The main g…

This study is testing whether drinking tart cherry juice can prevent nerve pain (neuropathy) caused by a common chemotherapy drug called paclitaxel. It will enroll 86 people with breast or ovarian cancer who are starting this type of chemo. Participants will be randomly assigned …

This study is testing whether custom-made, 3D-printed breast prostheses can improve comfort and satisfaction for people who have had a mastectomy and did not have breast reconstruction. Researchers will create personalized prostheses using 3D scans and compare them to traditional…

This study collects detailed information about side effects experienced by cancer patients receiving proton radiation therapy. Researchers will follow 5,000 patients to understand both short-term and long-term effects, aiming to predict risks and improve safety for future patient…

This study aims to understand why some breast cancer patients develop nerve damage (peripheral neuropathy) from the chemotherapy drug paclitaxel, while others do not. Researchers will analyze the stored DNA of 575 patients who previously received this treatment. By looking for ge…

This study aims to understand why some breast cancer patients develop severe high blood pressure when taking the drug bevacizumab. Researchers will analyze the DNA of about 350 patients who either did or did not experience this side effect. The goal is to find genetic markers tha…

This study aims to test a simple method for understanding the daily lives of breast cancer survivors. Researchers want to see if a 14-day mobile phone diary is a practical way to track daily stress and thinking patterns. They will recruit 30 diverse survivors who are at least fiv…

This study aims to identify blood markers that can predict which breast cancer patients might develop heart problems from chemotherapy. Researchers will collect blood samples from 200 patients before and after treatment to look for genetic clues. The goal is to help doctors inter…

This study is developing and testing a decision-making tool to help women with early-stage breast cancer choose their treatment options. Researchers will compare how the tool affects communication with doctors and decision-making satisfaction. The study involves 180 participants,…

This study aims to better understand the skin reactions that breast cancer patients experience during radiation therapy. Researchers will interview 20 patients about how these skin changes affect their physical comfort, emotions, and daily activities. The goal is to gather firsth…

This study is looking at whether taking a daily white button mushroom powder supplement for three months can change certain markers of inflammation and immune cells in the body. It involves 26 obese, postmenopausal women who are at high risk for developing breast cancer. The goal…

This study aims to see if adding a genetic risk score to standard breast cancer risk assessments helps African American and Hispanic women make more informed decisions about screening and prevention. Researchers will follow 50 women with elevated breast cancer risk for 10 years t…

This study aims to collect information from women getting routine mammograms to build a large database for future research. It will enroll 10,000 women without a history of breast cancer to gather their mammogram images, blood samples, and health information annually for five yea…

This study aims to better understand why some women with benign breast conditions develop cancer later. Researchers will analyze tissue samples, mammograms, and genetic information from 4,500 women who had benign breast biopsies. The goal is to identify patterns that predict futu…

This study is testing whether a multilingual AI chatbot named PERLA can help more cancer patients get important genetic testing. It compares patients who learn about testing from the chatbot to those who learn from a human genetics counselor. The goal is to see if this technology…

This study aims to better understand and measure cancer-related pain. Researchers will use a non-invasive brain scanner and virtual reality (VR) relaxation programs to see if VR can help reduce pain and the need for pain medication. The goal is to develop new, objective tools for…

This study aims to better understand hair loss caused by hormone therapy drugs used to treat breast cancer. Researchers will follow 170 women with breast cancer who are taking different types of hormone therapy. By having patients regularly report their hair loss symptoms, the st…

This study aims to understand how long-term tamoxifen treatment affects certain immune cells called neutrophils in breast cancer patients. Researchers will collect blood samples from 290 women with estrogen-positive breast cancer who have been taking tamoxifen for different lengt…

This study aims to understand how often women at a moderately increased risk for breast cancer follow through with recommended screening. Researchers will compare two groups: women with specific gene changes and women with a high calculated lifetime risk. By reviewing medical rec…

This study is testing whether an online self-monitoring platform is a useful tool for cancer patients. It aims to help patients track side effects and concerns about their oral cancer medications while they are at home. The research will see if using the app improves how patients…

This study aims to understand how breast cancer treatment affects sleep patterns and quality. Researchers will follow 100 patients with early-stage breast cancer, having them wear sleep trackers and complete surveys from treatment through recovery. The goal is to identify factors…

This study aims to understand why many breast cancer survivors stop attending their long-term follow-up appointments. Researchers will track 1500 women treated in 2017-2018 to see how many are lost to follow-up after five years. They will then try to contact those who have stoppe…

This study aims to understand how cancer-related genetic mutations differ among various ethnic populations. Researchers will collect blood or saliva samples from 1,800 cancer patients from diverse backgrounds to identify genetic patterns. The findings could help create more perso…

This study is testing a new radioactive dye for PET/CT scans to see if it can better show cancer cells in people with solid tumors, including ovarian, breast, and other cancers. Researchers want to see if this new imaging method can help measure a specific protein activity inside…

This study aims to create a collection of blood and tissue samples from patients whose breast cancer has returned or spread. Researchers will use these samples to learn more about how the cancer changes and responds to treatments over time. The goal is to build a resource that he…