BREAST CARCINOMA

This study tests a system called CONCURxP that uses a smart pill dispenser (WiseBag) and text message reminders to help people with metastatic breast cancer take their CDK4/6 inhibitor pills as prescribed. About 410 patients will be split into two groups: one gets the full system…

This early-phase trial tests AVA6000, a chemotherapy drug that is designed to activate only in tumors, potentially reducing side effects. About 158 adults with advanced solid tumors (like breast, ovarian, or salivary gland cancer) will receive the drug intravenously. The main goa…

This study tests two drugs together—disitamab vedotin and tucatinib—in people with advanced breast or stomach cancers that have a protein called HER2. The goal is to see if the combination is safe and shrinks tumors. About 172 participants will take part.

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This study tests a new drug called GTAEXS617 in people with advanced solid tumors (like lung, pancreatic, or ovarian cancer) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 230 p…

This study tests whether precisely targeted radiation (SBRT) can treat a few growing cancer spots in patients with metastatic breast cancer, allowing them to stay on their current systemic therapy instead of switching to a new drug. Researchers will also look at whether circulati…

This study tests whether a special vacuum dressing (negative pressure therapy) can reduce wound complications like infection, reopening, or slow healing after complex breast cancer surgery with reconstruction. About 254 women with risk factors like obesity or smoking will be rand…

This phase II trial is testing whether giving a shorter, stronger course of radiation before breast surgery is safer and works better than giving it after surgery for people with non-metastatic breast cancer. The study will enroll 120 participants with different breast cancer typ…

This phase 2 trial is testing a new, ultra-short radiation schedule for women with stage I-III breast cancer who have had a lumpectomy. Instead of the usual 3-4 weeks of daily radiation, this approach delivers the entire course in just 5 days. The goal is to see if this shorter t…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This early study at Mayo Clinic is testing whether a new 3D ultrasound technique can better tell if lymph nodes under the arm contain cancer in people with breast cancer. About 55 adults who already need a lymph node biopsy or have a clip placed will get both standard 2D and the …

This phase I trial is testing a new radioactive tracer called [18F]FTT, which is used with PET/CT scans to find tumor cells in people with solid tumors, including breast, ovarian, and other cancers. The study will enroll 300 participants and aims to see how well the tracer highli…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will review medical records from 750 women to see if the synthetic method works as well or better, with the added benefit of lower rad…

This study explores whether photoacoustic imaging—a technique that uses light and sound waves—can better detect breast cancer in women with dense breasts, where mammograms often fall short. Researchers will scan up to 400 women, including those with suspicious or confirmed breast…

This study is testing whether a blood test called a liquid biopsy can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue biopsies in 490 women. If the blood test works well, it could offer a less invasive way to sc…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this type of cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection …

Researchers at Mayo Clinic are testing a new breast ultrasound method to see if it can better detect breast cancer and measure how well a patient responds to treatment. The study will involve 550 adult volunteers with suspicious breast masses or biopsy-confirmed breast cancer. Pa…

This trial tests whether contrast-enhanced ultrasound (CEUS) combined with machine learning can more accurately tell if a breast mass is benign or malignant. 100 women with suspicious breast masses will receive CEUS with a contrast agent. The goal is to see if this approach can r…

This study tests a special type of mammogram called CESM, which uses a dye injected into a vein to make breast tissue and blood vessels clearer. The goal is to see if CESM is better than standard mammograms at finding the cause of nipple discharge and detecting breast cancer. Abo…

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen can safely reduce breast density, which is linked to cancer risk. About 200 women will take tamoxifen, and doctors will adjust the dose if needed to get t…

This study tests whether taking low-dose aspirin can lower inflammation and reduce the risk of breast cancer in women who have had a baby within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes. The…

This study tests whether adding high-dose omega-3 fatty acids to low-dose tamoxifen can lower breast cancer risk more than tamoxifen alone. It includes 66 overweight or obese postmenopausal women at increased risk for breast cancer. The goal is to see if the combination improves …

This study tests whether acolbifene or a low dose of tamoxifen can reduce breast cancer risk in premenopausal women at high risk. Both drugs block estrogen from reaching breast cells. Researchers will measure changes in breast tissue, blood, and mammograms over six months in 80 w…

This study tests whether using quilting stitches (which attach skin to muscle) with just one drain under the arm works as well as using two drains after mastectomy. The goal is to prevent seroma (fluid buildup), infection, and pain. Sixty women having a modified radical mastectom…

This phase 2 trial tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in breast and ovarian cancer patients. About 86 participants will be randomly assigned to receive either a high or low dose of the juice du…

This study tests a community program to increase cancer screening rates among low-income women in Ohio. The program includes patient education, coaching calls, and community outreach. Researchers will compare screening rates between groups that start the program early versus late…

This study tests whether using community health advocates—people who encourage their friends and family—can increase screening for breast and lung cancer. Researchers will enroll 800 participants and provide educational materials, patient navigation, and surveys. The goal is to s…

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This study compares two exercise programs for women receiving chemotherapy for early-stage breast cancer. One program uses a fixed amount of walking each week, while the other adjusts the amount based on how each woman responds. The goal is to see which approach better improves c…

This study tests whether a virtual exercise and education program can help breast cancer patients maintain their fitness, heart health, and quality of life while undergoing chemotherapy. About 120 patients with stage I-III breast cancer will be enrolled. Participants will attend …

This pilot study tests whether a wearable EEG headband (MUSE-S) that guides meditation can help breast cancer survivors who struggle with anxiety and insomnia. Twenty participants will use the headband at home, and researchers will track how often they use it and whether it impro…

This study tests whether doing breathing exercises at home can help reduce heart and lung side effects in people being treated for breast, head/neck, or lung cancer. The exercises are designed to strengthen breathing muscles and may be easier than regular aerobic exercise for pat…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests a decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms and helps patients discuss treatment priorities with their doctor. Researchers will enroll 2…

This study is testing a Chinese herbal cream (with 1% menthol) to see if it can temporarily relieve pain and itching on the chest after breast cancer radiotherapy. Forty women who have had a mastectomy and will receive radiation are being recruited. The cream is applied twice dai…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study tests whether custom 3D-printed external breast prostheses improve comfort, fit, and emotional well-being for women who have had a mastectomy without reconstruction. Fifty participants will receive a personalized prosthesis made from 3D scans of their chest. The goal i…

This study tests whether compounds from cannabis (CBD and THC) can reduce chronic nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 people will take part and report their symptoms over 12 weeks. The goal is to find a better …

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study follows 960 women at high risk for breast cancer to see if their diet's inflammatory potential is linked to cancer risk. Participants complete questionnaires and physical exams over time. The goal is to identify modifiable risk factors to improve prevention and early d…

This study tests whether community health forums called WE-CARE can help more rural and low-income women get screened for breast cancer and join clinical trials. The forums include educational sessions, survivor storytelling, and patient navigation to address barriers. Researcher…

This study tracks whether women at moderately increased risk for breast cancer get recommended screening MRIs within a year of genetic counseling. Researchers will also explore what makes it easier or harder for them to follow through. About 150 women aged 30 to 75 with certain g…

This study looks at how well patients recover after mastectomy and tissue expander placement when they stay in a special 'Care Hotel' instead of a hospital or going straight home. The Care Hotel offers a comfortable room with nursing care during the day and 24-hour video monitori…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor to fight cancer. The study involves 36 adults with invasive breast cancer who will receive radiation and have tumor …

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. It focuses on a process where neutrophils release web-like traps that may cause side effects. Researchers will study blood samples from 290 women with ER+ breast cance…

This study tracks hair loss in 170 women with breast cancer who are taking hormone therapy. Researchers want to learn how common hair loss is, when it starts, how long it lasts, and how severe it gets. Participants will fill out questionnaires about their hair loss and quality of…

This study is looking at how the immune system responds to breast and ovarian cancers. Researchers will analyze tumor and blood samples from 160 women before surgery to understand immune cell activity and find markers that might predict survival. The goal is to learn more about h…

This study looks at whether measuring body composition (like body fat) before and after breast reconstruction surgery can help predict outcomes. Researchers will enroll 40 women with breast cancer who are having a mastectomy followed by immediate reconstruction. The goal is to se…

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors pick the best second-line treatment for people with ER-positive, HER2-negative metastatic breast cancer. About 300 participants will be assigned to either endocrine therapy or chemotherapy bas…

This study is looking at how cancer genetic testing works in people from different ethnic backgrounds. Researchers will collect blood samples and genetic information from 1,800 adults with various solid tumors. The goal is to find cancer-related gene mutations and see if current …

This study from Mayo Clinic interviews breast cancer patients who are undergoing or have recently finished radiotherapy. The goal is to learn about their physical, emotional, and social experiences with radiation dermatitis (skin irritation from radiation). By collecting these pe…

This study examines DNA from 162 breast cancer patients who received chemotherapy and either did or did not develop congestive heart failure. Researchers want to find specific gene changes that might increase the risk of heart problems after treatment. The goal is to better under…

This study examines DNA from 575 breast cancer patients who received the chemotherapy drug paclitaxel. Researchers want to find genetic differences that explain why some patients develop nerve damage (peripheral neuropathy) while others do not. The goal is to identify biomarkers …

This study examines DNA from 354 breast cancer patients who took the drug bevacizumab. Some developed severe high blood pressure, while others did not. Researchers will compare their DNA to find genetic changes that might raise the risk of this side effect. The goal is to better …

This study tests whether a computer-generated character (PERLA) can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. Researchers will enroll 800 people with certain cancers, including breast, ovarian, pancreatic, and prostate canc…

This study follows 2,000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain or nausea over time. No treatme…

This Mayo Clinic study is recruiting 4,500 women who had a benign breast biopsy between 2002 and 2022. Researchers will examine tissue samples, mammograms, and genetic data to find clues about why some women later develop breast cancer. The goal is to improve risk prediction and …

This study collects tumor samples and medical information from 2000 people with breast cancer that has spread or come back. The goal is to create a resource for researchers to learn more about how the disease progresses and responds to treatments. No new treatments are tested her…

This study is testing a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect to support services, and manage barriers like transportation or finances. Researchers want to see if this approach im…

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource for future research on breast cancer and women's health. Participants provide a blood sampl…

This study aims to map the genetic makeup of breast and prostate cancers in patients treated through Brazil's public health system. Researchers will analyze tumor and normal DNA from 882 participants to build a national database. The goal is to better understand how genetics and …

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study tests whether an online self-monitoring platform helps patients with lung, colorectal, breast, or prostate cancer track medication safety events and concerns while taking oral anticancer drugs at home. Eighty adult patients currently on active cancer treatment will use…

This study tests a new way to find the first lymph node (sentinel node) during breast cancer surgery. Instead of using the usual armpit hairline as a guide, doctors will use ultrasound to mark the exact spot. The goal is to see if this leads to a smaller cut, less tissue damage, …

This study looks at how sleep changes in women with early-stage breast cancer during treatment. Researchers will track sleep patterns and check for links to stress, social support, and living environment. About 100 participants will wear a sleep monitor and answer surveys before,…

This study looks at whether eating white button mushrooms can lower inflammation and improve immune function in obese postmenopausal women who have a high risk of breast cancer. Researchers will measure changes in immune cells and inflammatory markers in the blood. The goal is to…

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study looks at whether holding a deep breath during breast cancer radiation therapy can lower the amount of radiation reaching the heart. Researchers will compare heart radiation doses in 400 women who use a special breathing device versus those who breathe normally. The goa…

This study is developing and testing a printed decision aid for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well women who receive the aid feel about their decisions ve…

This study tests a post-treatment support program for breast cancer survivors in Western New York. The program includes group sessions and one-on-one mentoring with a long-term survivor to help with self-assessments and connecting to resources. The goal is to see if this program …

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking (cognitive) changes in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants comp…

This study looks at 1500 women treated for breast cancer in India between 2017 and 2018 to see how many stopped coming to follow-up visits. Researchers will call or message those who are 'lost to follow-up' to ask about their health and find out why they stopped. The goal is to l…