DNA detective work: can genes predict dangerous blood pressure spike from cancer drug?
NCT ID NCT02610413
First seen Mar 30, 2026 · Last updated Jun 19, 2026 · Updated 15 times
Summary
This study examines DNA from 354 breast cancer patients who took the drug bevacizumab. Some developed severe high blood pressure, while others did not. Researchers will compare their DNA to find genetic changes that might raise the risk of this side effect. The goal is to better understand who is at risk, not to test a new treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Eastern Cooperative Oncology Group
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help doctors predict which patients are at risk for high blood pressure from bevacizumab, allowing safer treatment choices.
What could go wrong
This is an early exploratory study analyzing stored DNA samples, not testing a new treatment. It may not find clear genetic links, and any findings would need much more research before changing patient care.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.